Evidence map›Paper›PMID 37304260›Full record

ReviewFrontiers in immunology2023

Crosstalk between the gut microbiota and innate lymphoid cells in intestinal mucosal immunity.

Yuling Guo, Yujia Liu, Binqi Rui, Zengjie Lei, Xixi Ning, Yinhui Liu, Ming Li

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Colonic neoplasia and celiac disease: A systematic review.World journal of gastroenterology · 2025
    Pooled it
  2. Review
  3. Review
  4. Effects of Different Types ofFoods (Basel, Switzerland) · 2026
    Article
  5. Review
  6. Review
  7. Frontiers in cellular and infection microbiology · 2026
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Guardians within: Cross-talk between the gut microbiome and host immune system.World journal of gastrointestinal pathophysiology · 2025
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuling GuoDepartment of Microecology, College of Basic Medicine, Dalian Medical University, Dalian, China.
Yujia LiuDepartment of Microecology, College of Basic Medicine, Dalian Medical University, Dalian, China.
Binqi RuiDepartment of Microecology, College of Basic Medicine, Dalian Medical University, Dalian, China.
Zengjie LeiDepartment of Microecology, College of Basic Medicine, Dalian Medical University, Dalian, China.
Xixi NingDepartment of Microecology, College of Basic Medicine, Dalian Medical University, Dalian, China.
Yinhui LiuDepartment of Microecology, College of Basic Medicine, Dalian Medical University, Dalian, China.
Ming LiDepartment of Microecology, College of Basic Medicine, Dalian Medical University, Dalian, China.
Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human gastrointestinal mucosa is colonized by thousands of microorganisms, which participate in a variety of physiological functions. Intestinal dysbiosis is closely associated with the pathogenesis of several human diseases. Innate lymphoid cells (ILCs), which include NK cells, ILC1s, ILC2s, ILC3s and LTi cells, are a type of innate immune cells. They are enriched in the mucosal tissues of the body, and have recently received extensive attention. The gut microbiota and its metabolites play important roles in various intestinal mucosal diseases, such as inflammatory bowel disease (IBD), allergic disease, and cancer. Therefore, studies on ILCs and their interaction with the gut microbiota have great clinical significance owing to their potential for identifying pharmacotherapy targets for multiple related diseases. This review expounds on the progress in research on ILCs differentiation and development, the biological functions of the intestinal microbiota, and its interaction with ILCs in disease conditions in order to provide novel ideas for disease treatment in the future.

Indexed as

Gastrointestinal MicrobiomeHumansImmunity, InnateImmunity, MucosalIntestinal MucosaKiller Cells, Naturaldiseasesgut microbiotainnate lymphoid cellsintestinal mucosal immunitylamina propria

Identifiers

PMID37304260
PMCPMC10249960
OpenAlexW4378232460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.