Evidence map›Paper›PMID 37304053›Full record

ArticleFortune journal of health sciences2022

Immune Response to COVID-19 in India through Vaccination and Natural Infection.

Tresa Rani Sarraf, Shreyasi Maity, Arjun Ghosh, Suchandan Bhattacharjee, Arijit Pani, Kaushik Saha, Dhrubajyoti Chattopadhyay, Gourisankar Ghosh, Malini Sen

Open access · diamondAbstract read
In one paragraph

Article in Fortune journal of health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Tresa Rani SarrafCSIR-Indian Institute of Chemical Biology, 4 Raja Subodh Chandra Mullick Road, Kolkata 700032.
Shreyasi MaityCSIR-Indian Institute of Chemical Biology, 4 Raja Subodh Chandra Mullick Road, Kolkata 700032.
Arjun GhoshBiobharati Life Sciences, EN-35, Sector V, Kolkata 700091.
Suchandan BhattacharjeeBiobharati Life Sciences, EN-35, Sector V, Kolkata 700091.
Arijit PaniBiobharati Life Sciences, EN-35, Sector V, Kolkata 700091.
Kaushik SahaUniversity of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Dhrubajyoti ChattopadhyaySister Nivedita University, DG 1/2 New Town, Kolkata 700156.
Gourisankar GhoshUniversity of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Malini SenCSIR-Indian Institute of Chemical Biology, 4 Raja Subodh Chandra Mullick Road, Kolkata 700032.
University of California, San Diego · USTechno India Group (India) · IN

Funding

Investigation of Gene Regulation by NF-kappaB Transcription factorsR01GM085490 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, GOURISANKAR · 2009 to 2023
$3.8M
Suppressing Inflammation by Blocking IKK OligomerR01AI163327 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOURISANKAR GHOSH · 2022 to 2026
$2.6M
NIAID NIH HHS R01 AI163327NIGMS NIH HHS R01 GM085490
6 · The paper itself

Abstract

In India, COVID-19 (Corona Virus Disease-2019) continues to this day, although with subdued intensity, following two major waves of viral infection. Despite ongoing vaccination drives to curb the spread of COVID-19, the relative potential of the administered vaccines to render immune protection to the general population and their advantage over natural infection remain undocumented. In this study, we examined the humoral and cell-mediated immune responses induced by the two vaccines Covishield and Covaxin, in individuals living in and around Kolkata, India. We also compared the immune responses induced separately by vaccination and natural infection. Our results indicate that although Covishield generates a better humoral immune response toward SARS-CoV-2, both vaccines are almost equivalent in terms of cell-mediated immune response to the virus. Both Covishield and Covaxin, however, are more effective toward the wild-type virus than the Delta variant. Additionally, the overall immune response resulting from natural infection in and around Kolkata is not only similar to that generated by vaccination but the cell-mediated immune response to SARS-CoV-2 also lasts for at least ten months in some individuals after the viral infection.

Indexed as

CovaxinCOVID-19CovishieldRBD-WT and RBD-DELTASARS-CoV-2

Identifiers

PMID37304053
PMCPMC10257406
OpenAlexW4290774707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.