Evidence map›Paper›PMID 37303851›Full record

ArticleBioactive materials2023

M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator.

Yili Wang, Qiushui Lin, Hao Zhang, Sicheng Wang, Jin Cui, Yan Hu, Jinlong Liu, Mengmeng Li, Kun Zhang, Fengjin Zhou and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
23.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 151 citations in OpenAlex.

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  12. Macrophage Derived TGF-β Recruits BMSCs for Initiation of Bone Formation During Fracture Healing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yili WangInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Qiushui LinDepartment of Spine Surgery, First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Hao ZhangInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Sicheng WangInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Jin CuiInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Yan HuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Jinlong LiuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Mengmeng LiInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Kun ZhangDepartment of Orthopedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China.
Fengjin ZhouDepartment of Orthopedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China.
Yingying JingInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Zhen GengInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Jiacan SuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Shanghai University · CNXi'an Honghui Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture healing. Macrophages play a key role in the process of fracture healing by undergoing polarization into either M1 or M2 subtypes, which respectively exhibit pro-inflammatory or anti-inflammatory functions. Therefore, modulation of macrophage polarization to the M2 subtype is beneficial for fracture healing. Exosomes perform an important role in improving the osteoimmune microenvironment due to their extremely low immunogenicity and high bioactivity. In this study, we extracted the M2-exosomes and used them to intervene the bone repair in diabetic fractures. The results showed that M2-exosomes significantly modulate the osteoimmune microenvironment by decreasing the proportion of M1 macrophages, thereby accelerating diabetic fracture healing. We further confirmed that M2-exosomes induced the conversion of M1 macrophages into M2 macrophages by stimulating the PI3K/AKT pathway. Our study offers a fresh perspective and a potential therapeutic approach for M2-exosomes to improve diabetic fracture healing.

Indexed as

Diabetic fracture healingM2-exosomesMacrophage polarizationOsteoimmune microenvironmentPI3K/AKT signaling pathway

Identifiers

PMID37303851
PMCPMC10247878
OpenAlexW4378895568

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.