Evidence map›Paper›PMID 37303789›Full record

ArticleFrontiers in microbiology2023

Comparison of

Jemi Ong, Rose Godfrey, Alexa Nazarian, Joshua Tam, Brad M Isaacson, Paul F Pasquina, Dustin L Williams

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jemi OngDepartment of Biomedical Engineering, University of Utah, Salt Lake City, UT, United States.
Rose GodfreyDepartment of Orthopaedics, University of Utah, Salt Lake City, UT, United States.
Alexa NazarianWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, United States.
Joshua TamWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, United States.
Brad M IsaacsonDepartment of Orthopaedics, University of Utah, Salt Lake City, UT, United States.
Paul F PasquinaThe Center for Rehabilitation Sciences Research, Uniformed Services University, Bethesda, MD, United States.
Dustin L WilliamsDepartment of Biomedical Engineering, University of Utah, Salt Lake City, UT, United States.
University of Utah · USMassachusetts General Hospital · USUniformed Services University of the Health Sciences · USWalter Reed National Military Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bacterial biofilms readily develop on all medical implants, including percutaneous osseointegrated (OI) implants. With the growing rate of antibiotic resistance, exploring alternative options for managing biofilm-related infections is necessary. Antimicrobial blue light (aBL) is a unique therapy that can potentially manage biofilm-related infections at the skin-implant interface of OI implants. Antibiotics are known to have antimicrobial efficacy disparities between the planktonic and biofilm bacterial phenotypes, but it is unknown if this characteristic also pertains to aBL. In response, we developed experiments to explore this aspect of aBL therapy. Methods: We determined minimum bactericidal concentrations (MBCs) and antibiofilm efficacies for aBL, levofloxacin, and rifampin against Results: aBL had the most significant efficacy disparity between the planktonic and biofilm phenotypes (a 2.5 log Discussion/conclusion: We determined that phenotype is an important characteristic to consider when determining aBL parameters for treating OI implant infections. Future research would benefit from expanding these findings against clinical

Indexed as

antibioticsbiofilmsblue lightinfectionosseointegration

Identifiers

PMID37303789
PMCPMC10248220
OpenAlexW4378232172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.