Evidence map›Paper›PMID 37303736›Full record

ArticleOncology research2023

Thioredoxin domain-containing protein 9 protects cells against UV-B-provoked apoptosis via NF-κB/p65 activation in cutaneous squamous cell carcinoma.

Zhixun Xiao, Qiuyun Xu, Haiqing Wang, Xiaotong Zhou, Yanting Zhu, Chengbei Bao, Lihong Chen, Peng Zhang, Min Lin, Chao Ji and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zhixun XiaoDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
Qiuyun XuDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
Haiqing WangDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
Xiaotong ZhouCancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
Yanting ZhuDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
Chengbei BaoDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
Lihong ChenDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
Peng ZhangDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
Min LinDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
Chao JiDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
Ting GongCentral Laboratory, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
First Affiliated Hospital of Fujian Medical University · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous squamous cell carcinoma (cSCC), a type of non-melanoma skin cancer (NMSC), is the most common malignancy worldwide. Thioredoxin (TXN) domain-containing protein 9 (TXNDC9) is a member of the TXN family that is important in cell differentiation. However, the biological function of this protein in cancer, particularly cSCC, is still unknown. In the present study, our experiments revealed the protective effects of TXNDC9 on UV-B-irritated cSCC cells. The initial findings showed that TXNDC9 is significantly upregulated in cSCC tissue and cells compared to normal skin tissue and keratinocytes. UV-B radiation robustly induces the expression of TXNDC9, and UV-B-induced cSCC cell death is boosted by TXNDC9 deficiency. Moreover, cSCC cells lacking TXNDC9 displayed attenuated activation of the NF-κB pathway. Additional studies by inhibiting TXNDC9 confirmed this finding, as TXNDC9 deficiency attenuated UV-B radiation-induced translocation of NF-κB p65 from the cytoplasm to the nucleus of cSCC. In conclusion, our work demonstrates the biological roles of TXNDC9 in cSCC progression and may provide a novel therapeutic target to treat cSCC in the future.

Indexed as

Carcinoma, Squamous CellSkin NeoplasmsThioredoxinsApoptosisHumansNF-kappa BTranscription Factor RelANF-kappa BRELA protein, humanThioredoxinsTranscription Factor RelATXNDC9 protein, humanApoptosisCutaneous squamous cell carcinoma (cSCC)NF-κB pathwayTXNDC9Ultra Violet-B (UV-B) radiation

Identifiers

PMID37303736
PMCPMC10207983
OpenAlexW4322721984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.