Evidence map›Paper›PMID 37303677›Full record

ArticleAmerican journal of translational research2023

Neferine mediated TGF-β/ERK signaling to inhibit fibrosis in endometriosis.

Yue Xia, Ying Guo, Jianhua Zhou, Limin Fan, Jiani Xie, Yili Wang, Huilan Du, Xiaorong Ni

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yue XiaDepartment of Gynecology, Shanghai Traditional Chinese Medicine Hospital, Shanghai University of Traditional Chinese Medicine Shanghai 200071, China.
Ying GuoDepartment of Gynecology, Shanghai Traditional Chinese Medicine Hospital, Shanghai University of Traditional Chinese Medicine Shanghai 200071, China.
Jianhua ZhouDepartment of Gynecology, Shanghai Traditional Chinese Medicine Hospital, Shanghai University of Traditional Chinese Medicine Shanghai 200071, China.
Limin FanThe Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine Shanghai 200092, China.
Jiani XieDepartment of Gynecology, Shanghai Traditional Chinese Medicine Hospital, Shanghai University of Traditional Chinese Medicine Shanghai 200071, China.
Yili WangDepartment of Gynecology, Shanghai Traditional Chinese Medicine Hospital, Shanghai University of Traditional Chinese Medicine Shanghai 200071, China.
Huilan DuDepartment of Gynecology, Hebei University of Chinese Medicine Shijiazhuang 050200, Hebei, China.
Xiaorong NiDepartment of Gynecology, Shanghai Traditional Chinese Medicine Hospital, Shanghai University of Traditional Chinese Medicine Shanghai 200071, China.
Shanghai University of Traditional Chinese Medicine · CNHebei University of Chinese Medicine · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the mechanism of Neferine in treating endometriosis fibrosis by TGF-β/ERK signaling pathway through a combination of network pharmacological analysis of Lotus embryos,

methodsThe active ingredients of the drug lotus embryos, the drug targets and the targets of endometriosis were determined from the TCMSP database, the Swiss Target Prediction database and GeneCard and Online Mendelian Inheritance in Man. The String database and Cytoscape 3.6.3 software were used to construct the network of common target protein interactions between drug and disease, as well as the target network. GO and KEGG enrichment analysis of the common targets was performed. We designed endometriosis mouse models with Neferine to investigate the therapeutic effect of Neferine on the fibrosis model of endometriosis and its mechanism of action. Different methods were used to evaluate the treated endometriotic lesion tissue and the untreated ectopic lesion tissue. The 12Z cells (human endometriosis immortalized cells) were cultured

resultsThe results of GO function and KEGG enrichment analysis showed that the role pathways of lotus germ were TGF-β signaling pathway, ERK1/2 signaling pathway, IL-17 signaling pathway, TNF signaling pathway, AGE-RAGE signaling pathway, and PI3K-Akt signaling pathway. Neferine which is one of the effective active ingredients of lotus germ, significantly inhibited the expression of fibronectin, collagen I, connective tissue growth factor, and smooth muscle actin by activating the TGF-β/ERK pathway

conclusionNeferine inhibits the progression of endometriosis both

Indexed as

endometriosisfibrosisNeferineTGF-β/ERK signaling pathway

Identifiers

PMID37303677
PMCPMC10250984
OpenAlexW4380291757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.