Evidence map›Paper›PMID 37303621›Full record

ArticleAmerican journal of translational research2023

Moxibustion ameliorated age-related alterations in neurological behavior and gut microbiota in mice.

Yao Lin, Min Xing, Nan Liu, Xia-Li Ouyang, Rui He, Chang Huang, Qin Yao, Ya-Jie Liu, Yue-Ping Huang, Ying Xue and 4 more

Abstract read
In one paragraph

Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yao LinSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine Beijing 102488, PR China.
Min XingSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, PR China.
Nan LiuBeijing Increasepharm Safety and Efficacy Co., Ltd. Beijing 102206, PR China.
Xia-Li OuyangSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine Beijing 102488, PR China.
Rui HeSchool of Life Sciences, Beijing University of Chinese Medicine Beijing 102488, PR China.
Chang HuangSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine Beijing 102488, PR China.
Qin YaoSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine Beijing 102488, PR China.
Ya-Jie LiuSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine Beijing 102488, PR China.
Yue-Ping HuangSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine Beijing 102488, PR China.
Ying XueSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine Beijing 102488, PR China.
Zhong-Yu WangSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, PR China.
Dan-Chen YangSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, PR China.
Li HanSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, PR China.
Bai-Xiao ZhaoSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine Beijing 102488, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo observe the anti-aging effects of moxibustion on age-related alterations in middle-aged mice.

methodsThirty, 9-month-old, male ICR mice were randomly divided into the moxibustion and control groups (N = 15). Mice in the moxibustion group were given mild moxibustion at the Guanyuan acupoint for 20 minutes every other day. After 30 treatments, neurobehavior tests, lifespan, gut microbiota composition and splenic gene expression were observed in the mice.

resultsMoxibustion improved the locomotor activity as well as motor function, activated the SIRT1-PPARα signaling pathway, ameliorated age-related alterations in gut microbiota, and affected the expression of genes related to energy metabolism in spleen.

conclusionMoxibustion ameliorated age-related alterations in neurobehavior and gut microbiota in middle-aged mice.

Indexed as

Agingbehaviorgut microbiotalifespanmoxibustiontranscriptome

Identifiers

PMID37303621
PMCPMC10251009

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.