ArticleAmerican journal of translational research2023
Safety of photodynamic therapy combined with surgical excision in patients with actinic keratosis and risk factors for secondary cutaneous squamous cell carcinoma.
Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Photodynamic Therapy for Keratinocytic Precancerous Lesions and Non-Melanoma Skin Cancer: A Narrative Review.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the efficacy of photodynamic therapy combined with surgical excision on the prognosis of patients with actinic keratosis (AK) and to analyze the risk factors for secondary cutaneous squamous cell carcinoma (cSCC).
methodsClinical data of 114 patients with AK treated at the West China Hospital from March 2014 to November 2018 were enrolled to this retrospective analysis. Among them 55 patients who underwent surgical resection alone were the control group (CG) and the other 59 who received photodynamic therapy combined with surgical resection were in the research group (RG). The treatment efficacy, lesion area, quality of life, incidence of adverse effects, and incidence of secondary sSCC in 3 years were compared, and the risk factors for sSCC were analyzed by multivariate logistics analysis.
resultsThe treatment efficacy of the RG was dramatically higher than that of the CG (P<0.05), and there was no obvious difference in the incidence of adverse reactions between the two groups (P>0.05). The lesion area and dermatology life quality index of the RG were dramatically lower than those of the CG after treatment (P<0.05), and the 3-year incidence of secondary cSCC in the RG was not statistically different from that of the OG (P>0.05). A greater number of lesion sites, a family history of tumor, and a history of skin disease were independent risk factors for secondary cSCC.
conclusionPhotodynamic therapy combined with surgical excision has better therapeutic efficacy in AK with a high safety.
Indexed as
Identifiers
37303615PMC10251020W4380290591What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.