Evidence map›Paper›PMID 37303517›Full record

ReviewHeliyon2023

A comprehensive insight on the challenges for COVID-19 vaccine: A lesson learnt from other viral vaccines.

Rahul Soloman Singh, Ashutosh Singh, Gladson David Masih, Gitika Batra, Amit Raj Sharma, Rupa Joshi, Ajay Prakash, Benjamin Suroy, Phulen Sarma, Manisha Prajapat and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Rahul Soloman SinghDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Ashutosh SinghDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Gladson David MasihDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Gitika BatraDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Amit Raj SharmaDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Rupa JoshiDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Ajay PrakashDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Benjamin SuroyDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Phulen SarmaDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Manisha PrajapatDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Hardeep KaurDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Anusuya BhattacharyyaDepartment of Ophthalmology, Government Medical College & Hospital, Sector-32, Chandigarh, 160030, India.
Sujata UpadhyayDepartment of Physiology, Dr. Harvansh Singh Judge Institute of Dental Sciences & Hospital, Panjab University, Chandigarh, 160014, India.
Bikash MedhiDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Post Graduate Institute of Medical Education and Research · INGovernment Medical College and Hospital · INPanjab University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to comprehensively analyze previous viral vaccine programs and identify potential challenges and effective measures for the COVID-19 vaccine program. Previous viral vaccine programs, such as those for HIV, Zika, Influenza, Ebola, Dengue, SARS, and MERS, were evaluated. Paramount challenges were identified, including quasi-species, cross-reactivity, duration of immunity, revaccination, mutation, immunosenescence, and adverse events related to viral vaccines. Although a large population has been vaccinated, mutations in SARS-CoV-2 and adverse events related to vaccines pose significant challenges. Previous vaccine programs have taught us that predicting the final outcome of the current vaccine program for COVID-19 cannot be determined at a given state. Long-term follow-up studies are essential. Validated preclinical studies, long-term follow-up studies, alternative therapeutic approaches, and alternative vaccines are necessary.

Indexed as

COVID-19Delta variantDengueEbolaHIVInfluenzaMERSOmicronSARSVaccineZika

Identifiers

PMID37303517
PMCPMC10245239
OpenAlexW4379644981

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.