ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023
White matter hyperintensity shape is associated with long-term dementia risk.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06010511 (White Matter Hyperintensity Shape and Glymphatics), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
White Matter Hyperintensity Shape and Glymphatics
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Imaging markers of cerebral small vessel disease are associated with Alzheimer's disease: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Cerebral "Dirty-Appearing" White Matter in Relation to Cognitive Decline and Dementia Risk in Community-Dwelling Older Adults.Neurology · 2026Article
- The potential of low-field MRI for global dementia care.Nature reviews. Neurology · 2026Review
- Retinal Microvascular Dysfunction Reflects Vascular and Alzheimer's-Related Pathology in Dementia With Lewy Bodies.CNS neuroscience & therapeutics · 2026Article
- The association of estimated glucose disposal rate with white matter hyperintensities: A large prospective cohort study.The journal of prevention of Alzheimer's disease · 2026Article
- Retinal microvascular dysfunction in mild cognitive impairment: Associations with cerebral small vessel disease, plasma biomarkers, and cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The strip-shaped deep white matter hyperintensities may be related to neurodegeneration: A study based on diffusion tensor imaging.PloS one · 2026Article
- Quantifying White Matter Hyperintensities: Automated Volumetry Compared with Visual Grading Scales.Medicina (Kaunas, Lithuania) · 2025Article
- Retinal microvascular alterations reflect cerebral small vessel disease burden in frontotemporal dementia: a multimodal OCTA-MRI Study.Alzheimer's research & therapy · 2025Article
- The White Matter Hyperintensity Shape and Brain Clearance (WHIMAS) Study for Identification of Novel 7T Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease: Protocol for a Cross-Sectional Study.JMIR research protocols · 2025Article
- Relationships between multimodal ocular imaging and white matter hyperintensity volume.Quantitative imaging in medicine and surgery · 2025Article
- Retinal microvascular alterations in Alzheimer's disease: Linking blood plasma biomarkers and cerebral small vessel pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- APOE ε2 is associated with reduced risk of early post-stroke cognitive impairment but not with long-term functional outcome.BMC neurology · 2025Article
- Choroidal Vascular Volume, White Matter Hyperintensity, and Their Interaction With Cognitive Function in Aging Adults.Journal of the American Heart Association · 2025Article
- Atrophy trajectories in Alzheimer's disease: how sex matters.Alzheimer's research & therapy · 2025Article
- Cognitive implications and associated transcriptomic signatures of distinct regional iron depositions in cerebral small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Extension of TNMR in biomedicine · 2025Article
- The Interaction Between Cognitive Abilities and White Matter Hyperintensity Phenotypes: A Novel Perspective on Bidirectional Causality.Brain and behavior · 2025Article
- Progress of radiomics research on white matter hyperintensity lesions.Frontiers in neurology · 2025Review
- The association of structural versus load-dependent large artery stiffness mechanisms with cerebrovascular damage and cortical atrophy in humans.GeroScience · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
introductionWe aimed to investigate the association between white matter hyperintensity (WMH) shape and volume and the long-term dementia risk in community-dwelling older adults.
methodsThree thousand seventy-seven participants (mean age: 75.6 ± 5.2 years) of the Age Gene/Environment Susceptibility (AGES)-Reykjavik study underwent baseline 1.5T brain magnetic resonance imaging and were followed up for dementia (mean follow-up: 9.9 ± 2.6 years).
resultsMore irregular shape of periventricular/confluent WMH (lower solidity (hazard ratio (95% confidence interval) 1.34 (1.17 to 1.52), p < .001) and convexity 1.38 (1.28 to 1.49), p < .001); higher concavity index 1.43 (1.32 to 1.54), p < .001) and fractal dimension 1.45 (1.32 to 1.58), p < .001)), higher total WMH volume (1.68 (1.54 to 1.87), p < .001), higher periventricular/confluent WMH volume (1.71 (1.55 to 1.89), p < .001), and higher deep WMH volume (1.17 (1.08 to 1.27), p < .001) were associated with an increased long-term dementia risk. DISCUSSION: WMH shape markers may in the future be useful in determining patient prognosis and may aid in patient selection for future preventive treatments in community-dwelling older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.