SynthesisThe British journal of surgery2023
Impact of surgical-site infection on health utility values: a meta-analysis.
Synthesis in The British journal of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Negative pressure wound therapy for the prevention of surgical site infections in orthopedic and trauma surgery: a systematic review and meta-analysis of RCTs.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025Pooled it
- Systematic review and meta-analysis of outcomes associated with incisional and organ/space surgical site infections in abdominal surgery patients.Antimicrobial resistance and infection control · 2025Pooled it
- Trial
- Distribution of putative SSI risk factors in adults undergoing open reduction and fixation of long bone fracture.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Observational
- Effectiveness of prophylactic single-dose IV antibiotic versus postoperative multi-dose oral antibiotic regimen for preventing surgical site infections: A prospective comparative study.Turkish journal of surgery · 2026Article
- What preoperative testing is needed in patients undergoing treatment for unruptured intracranial aneurysms? Optimizing value-based care based on perioperative risk: a cost effectiveness analysis.Neurosurgical review · 2026Article
- A Cost-Utility Analysis of Surgical Site Infection Prevention: Broadening the Scope.Applied health economics and health policy · 2026Article
- Reducing surgical site infection in emergency colorectal surgery: the case for topical tranexamic acid.International journal of colorectal disease · 2025Article
- Predicting Surgical Site Infection after Lumbar Laminectomy and Discectomy: A Cutting-edge Algorithmic Approach by Incorporating Ensembled Stacking into the Current State-of-the-art for Automated Machine Learning.Neurosurgical review · 2025Article
- Pilot Study: Prospective, First-in-human Clinical Evaluation of a Novel Tissue Apposition Device (ENIVO) Following Simple Unilateral Mastectomy.Plastic and reconstructive surgery. Global open · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundSurgical-site infections (SSIs) are recognized as negatively affecting patient quality of life. No meta-analysis of SSI utility values is available in the literature to inform estimates of this burden and investment decisions in prevention.
methodsA systematic search of PubMed, MEDLINE, CINAHL, and the National Health Service Economic Evaluation Database was performed in April 2022 in accordance with PROSPERO registration CRD 42021262633. Studies were included where quality-of-life data were gathered from adults undergoing surgery, and such data were presented for those with and without an SSI at similar time points. Two researchers undertook data extraction and quality appraisal independently, with a third as arbiter. Utility values were converted to EuroQol 5D (EQ-5D™) estimates. Meta-analyses were conducted using a random-effects model across all relevant studies, with subgroup analyses on type and timing of the SSI.
resultsIn total, 15 studies with 2817 patients met the inclusion criteria. Six studies across seven time points were used in the meta-analysis. The pooled mean difference in EQ-5D™ utility in all studies combined was -0.08 (95 per cent c.i. -0.11 to -0.05; prediction interval -0.16 to -0.01; I2 = 40 per cent). The mean difference in EQ-5D™ utility associated with deep SSI was -0.10 (95 per cent c.i. -0.14 to -0.06; I2 = 0 per cent) and the mean difference in EQ-5D™ utility persisted over time.
conclusionThe present study provides the first synthesized estimate of SSI burden over the short and long term. EQ-5D™ utility estimates for a range of SSIs are essential for infection prevention planning and future economic modelling.
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