ArticleCritical care (London, England)2023
Influence of gender on age-associated in-hospital mortality in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study.
Article in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Carrageenan-induced immunothrombotic models in rodents (Review).Experimental and therapeutic medicine · 2026Review
- A mouse model of sepsis-associated DIC induced by Kappa-carrageenan and Lipopolysaccharides: Establishment and characteristics.Journal of advanced research · 2026Article
- Testosterone and androgen receptor pathway modulation in sepsis: immunometabolic mechanisms and therapeutic implications - a scoping review.Frontiers in endocrinology · 2026Article
- Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis.Clinical and translational medicine · 2026Article
- Analysis of heart rate variability in critical septic patients using a smartphone application: a prospective cohort study.Frontiers in medicine · 2026Article
- The prognostic value of the neutrophil‑to‑platelet ratio for predicting postoperative sepsis complications after ureteroscopic lithotripsy.Translational andrology and urology · 2025Article
- Sex differences in sepsis outcomes across the lifespan: a population-based cohort study in Germany.Critical care (London, England) · 2025Article
- Diagnostic Clinical Predictors of Early Recovery from Stone-Induced Systemic Inflammatory Response Syndrome After Urgent Decompression.Diagnostics (Basel, Switzerland) · 2025Article
- Raman Spectroscopy Can Identify Acute and Persistent Biochemical Changes in Leukocytes From Patients With COVID-19 and Non-COVID-19-Associated Sepsis.Biotechnology journal · 2025Article
- The Prognostic Utility of Pathophysiologically Distinct Biomarkers for Renal Outcomes in Sepsis: A Prospective ICU Cohort Study.Journal of clinical medicine · 2025Article
- Association between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV database.European journal of medical research · 2025Article
- Risk factors for in-hospital mortality in surgical patients with abdominal sepsis in China: a nested case-control study.BMJ open · 2025Article
- Inflammatory burden index as a predictor of mortality in septic patients: a retrospective study using the MIMIC-IV database.BMC infectious diseases · 2025Article
- Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic Markers.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Variations in capillary and serum lactates levels based on different etiologies of septic patients in the emergency department.Frontiers in medicine · 2025Article
- Influence of underlying condition and performance of sepsis bundle in very old patients with sepsis: a nationwide cohort study.Annals of intensive care · 2024Article
- Epidemiology of sepsis-associated acute kidney injury in critically ill patients: a multicenter, prospective, observational cohort study in South Korea.Critical care (London, England) · 2024Observational
- Sex matters: Is it time for a SOFA makeover?Critical care (London, England) · 2024Article
- Age Distribution and Clinical Results of Critically Ill Patients above 65-Year-Old in an Aging Society: A Retrospective Cohort Study.Tuberculosis and respiratory diseases · 2024Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundNumerous epidemiological studies investigating gender-dependent clinical outcomes in sepsis have shown conflicting evidence. This study aimed to investigate the effect of gender on in-hospital mortality due to sepsis according to age group.
methodsThis study used data from the Korean Sepsis Alliance, an ongoing nationwide prospective multicenter cohort from 19 participating hospitals in South Korea. All adult patients diagnosed with sepsis in the emergency departments of the participating hospitals between September 2019 and December 2021 were included in the analysis. Clinical characteristics and outcomes were compared between male and female. Eligible patients were stratified by age into 19-50 years, 50-80 years, and ≥ 80 years old individuals.
resultsDuring the study period, 6442 patients were included in the analysis, and 3650 (56.7%) were male. The adjusted odds ratio (OR) [95% confidence interval (CI)] for in-hospital mortality for male compared with female was 1.15 (95% CI = 1.02-1.29). Interestingly, in the age 19-50 group, the risk of in-hospital mortality for males was significantly lower than that of females [0.57 (95% CI = 0.35-0.93)]. For female, the risk of death remained relatively stable until around age 80 (P for linearity = 0.77), while in males, there was a linear increase in the risk of in-hospital death until around age 80 (P for linearity < 0.01). Respiratory infection (53.8% vs. 37.4%, p < 0.01) was more common in male, whereas urinary tract infection (14.7% vs. 29.8%, p < 0.01) was more common in female. For respiratory infection, male had significantly lower in-hospital mortality than female in the age 19-50 groups (adjusted OR = 0.29, 95% CI = 0.12-0.69).
conclusionsGender may influence age-associated sepsis outcomes. Further studies are needed to replicate our findings and fully understand the interaction of gender and age on the outcomes of patients with sepsis.
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