Evidence map›Paper›PMID 37303001›Full record

ArticleMikrochimica acta2023

Electrochemical monitoring of enzymatic cleavage in nanochannels with nanoparticle-based enhancement: determination of MMP-9 biomarker.

David Valero-Calvo, Celia Toyos-Rodriguez, Francisco Javier García-Alonso, Alfredo de la Escosura-Muñiz

Abstract read
In one paragraph

Article in Mikrochimica acta, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David Valero-CalvoNanoBioAnalysis Group, Department of Physical and Analytical Chemistry, University of Oviedo, Julián Claveria 8, 33006, Oviedo, Spain.
Celia Toyos-RodriguezNanoBioAnalysis Group, Department of Physical and Analytical Chemistry, University of Oviedo, Julián Claveria 8, 33006, Oviedo, Spain.
Francisco Javier García-AlonsoBiotechnology Institute of Asturias, University of Oviedo, Santiago Gascon Building, 33006, Oviedo, Spain.
Alfredo de la Escosura-MuñizNanoBioAnalysis Group, Department of Physical and Analytical Chemistry, University of Oviedo, Julián Claveria 8, 33006, Oviedo, Spain. alfredo.escosura@uniovi.es.ORCID http://orcid.org/0000-0002-9600-0253

Funding

Gobierno del Principado de Asturias SV-PA-21-AYUD/2021/51323Ministerio de Ciencia e Innovación MCI-21-PID2020-115204RB-I00Ministerio de Ciencia e Innovación PRE2018-084953Ministerio de Ciencia e Innovación PRE2021-097567Ministerio de Ciencia e Innovación RyC-2016-20299
6 · The paper itself

Abstract

For the first time the use of nanoparticles as carriers of an enzymatic substrate immobilized inside nanoporous alumina membranes is proposed with the aim of amplifying the nanochannel blocking produced and, consequently, improving the efficiency of an enzyme determination through enzymatic cleavage. Streptavidin-modified polystyrene nanoparticles (PSNPs) are proposed as carrier agents, contributing to the steric and the electrostatic blockage due to the charge they present at different pH values. Electrostatic blockage is the predominant effect that governs the blockage in the interior of the nanochannel and is dependent not just in the charge inside the channel, but also in the polarity of the redox indicator used. Hence, the effect of using negatively charged ([Fe(CN)

Indexed as

Matrix Metalloproteinase 9NanoparticlesAluminum OxideBiomarkersReproducibility of ResultsAluminum OxideBiomarkersMatrix Metalloproteinase 9ElectrochemicalEnzymatic cleavageMMP-9NanochannelsNanoparticlesNanopores

Identifiers

PMID37303001
PMCPMC10258169

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.