Evidence map›Paper›PMID 37302999›Full record

ArticleJournal of cancer research and clinical oncology2023

Expression of pyroptosis-related genes are correlated with immune microenvironment and predict prognosis in ESCA.

Youmeng Shi, Qiuxing Yang, Guomei Tai, Xudong Chen

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Youmeng Shi *Department of Radiotherapy, Nantong Tumor Hospital and Nantong University, Nantong, China.
Qiuxing Yang *Cancer Research Center Nantong, Nantong Tumor Hospital and Affiliated Tumor Hospital of Nantong University, Nantong, China.ORCID http://orcid.org/0000-0001-9598-0424
Guomei TaiDepartment of Radiotherapy, Nantong Tumor Hospital and Affiliated Tumor Hospital of Nantong University, Nantong, China. guomeitai@163.com.ORCID http://orcid.org/0000-0001-7001-1790
Xudong ChenDepartment of Pathology, Nantong Tumor Hospital and Affiliated Tumor Hospital of Nantong University, Nantong, China. chenxudong@ntu.edu.cn.

Funding

Nantong Science and Technology Bureau JC22022093
6 · The paper itself

Abstract

objectivesPyroptosis-related genes (PRGs) are abnormally expressed in a variety of gastrointestinal tumors, this study aimed to investigate the role of pyroptosis genes in assessing the prognosis of esophageal cancer (ESCA).

methodsThrough consensus clustering, we identified two subtypes associated with PRGs. After Lasso regression and multivariate Cox regression analysis, a polygenic signature based on six prognostic PRGS was constructed. Afterwards, we combined the risk score with clinical predictors to construct and validate a PRGs-associated ESCA prognostic model.

resultsThrough analysis, we Successfully constructed and validated a PRGs-associated ESCA prognostic model that predicts ESCA survival and correlates with the tumor immune microenvironment.

conclusionBased on PRGs features, we established a new ESCA hierarchical model. This model has important clinical implications for ESCA patients, both in terms of assessing prognosis and in terms of targeted and immunotherapy.

Indexed as

Esophageal NeoplasmsPyroptosisCluster AnalysisHumansImmunotherapyPrognosisTumor MicroenvironmentEsophagus canceImmune microenvironmentPrognosisPyroptosis

Identifiers

PMID37302999
PMCPMC10423108

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.