Evidence map›Paper›PMID 37302554›Full record

ArticleThe Journal of biological chemistry2023

A new member of the flavodoxin superfamily from Fusobacterium nucleatum that functions in heme trafficking and reduction of anaerobilin.

Alexandra K McGregor, Anson C K Chan, Megan D Schroeder, Long T M Do, Gurpreet Saini, Michael E P Murphy, Kirsten R Wolthers

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alexandra K McGregorDepartment of Chemistry, University of British Columbia, Kelowna, Canada.
Anson C K ChanDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, Canada.
Megan D SchroederDepartment of Chemistry, University of British Columbia, Kelowna, Canada.
Long T M DoDepartment of Chemistry, University of British Columbia, Kelowna, Canada.
Gurpreet SainiDepartment of Chemistry, University of British Columbia, Kelowna, Canada.
Michael E P MurphyDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, Canada.
Kirsten R WolthersDepartment of Chemistry, University of British Columbia, Kelowna, Canada. Electronic address: kirsten.wolthers@ubc.ca.
University of British Columbia · CA

Funding

CIHR
6 · The paper itself

Abstract

Fusobacterium nucleatum is an opportunistic oral pathogen that is associated with various cancers. To fulfill its essential need for iron, this anaerobe will express heme uptake machinery encoded at a single genetic locus. The heme uptake operon includes HmuW, a class C radical SAM-dependent methyltransferase that degrades heme anaerobically to release Fe

Indexed as

FlavodoxinFusobacterium nucleatumHemeTetrapyrrolesBacterial ProteinsBiological TransportFlavin MononucleotideFusobacterium InfectionsGenes, BacterialHumansHydroquinonesIronOxidation-ReductionProtein DomainsProtoporphyrinsanaerobilinBacterial ProteinsFlavin MononucleotideFlavodoxinHemehydroquinoneHydroquinonesIronprotoporphyrin IXProtoporphyrinsTetrapyrrolesflavinflavodoxinFusobacterium nucleatumhemeradical SAM

Identifiers

PMID37302554
PMCPMC10404700
OpenAlexW4380182409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.