Evidence map›Paper›PMID 37302348›Full record

ArticleTranslational oncology2023

COVID-19 severity and cardiovascular outcomes in SARS-CoV-2-infected patients with cancer and cardiovascular disease.

Melissa Y Y Moey, Cassandra Hennessy, Benjamin French, Jeremy L Warner, Matthew D Tucker, Daniel J Hausrath, Dimpy P Shah, Jeanne M DeCara, Ziad Bakouny, Chris Labaki and 58 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04354701 (The COVID-19 and Cancer Consortium), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04354701 active not recruitingnot on this map

The COVID-19 and Cancer Consortium (CCC19) Registry

Typeobservational_patient_registrySponsorVanderbilt-Ingram Cancer CenterRan2020 to 2029Enrolled19,275ConditionsCOVID-19, Invasive Malignancy (Any Type)ArmsWeb-based REDCap survey
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

68 authors at 20 institutions in 3 countries.

Melissa Y Y MoeyDepartment of Cardiovascular Disease, Vidant Medical Center/East Carolina University, Greenville, NC, United States.
Cassandra HennessyDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States.
Benjamin FrenchDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States.
Jeremy L WarnerVanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, United States; Department of Medicine, Division of Hematology/Oncology, Vanderbilt University, Nashville, TN, United States; Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, United States.
Matthew D TuckerDepartment of Medicine, Division of Hematology/Oncology, Vanderbilt University, Nashville, TN, United States.
Daniel J HausrathDepartment of Medicine, Division of Hematology/Oncology, Vanderbilt University, Nashville, TN, United States.
Dimpy P ShahMays Cancer Center at UTHealth San Antonio MD Anderson, San Antonio, TX, United States.
Jeanne M DeCaraSection of Cardiology, University of Chicago Medical Center, Chicago, IL, United States.
Ziad BakounyDana-Farber Cancer Institute, Boston, MA, United States.
Chris LabakiDana-Farber Cancer Institute, Boston, MA, United States.
Toni K ChoueiriDana-Farber Cancer Institute, Boston, MA, United States.
Susan DentDuke Cancer Institute, Duke University Medical Center, Durham, NC, United States.
Nausheen AkhterDivision of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Roohi Ismail-KhanCardio-Oncology Program, Division of Cardiovascular Medicine, University of South Florida Morsani College of Medicine and Moffitt Cancer Center, Tampa, FL, United States.
Lisa TachikiUniversity of Washington, Seattle, WA, United States; Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
David SloskyCardio-Oncology Program, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Tamar S PolonskyDepartment of Medicine, University of Chicago, Chicago, IL, United States.
Joy A AwosikaUniversity of Cincinnati Cancer Center, Cincinnati, OH, United States.
Audrey CragoUniversity of Cincinnati Cancer Center, Cincinnati, OH, United States.
Trisha Wise-DraperUniversity of Cincinnati Cancer Center, Cincinnati, OH, United States.
Nino BalanchivadzeHenry Ford Cancer Institute, Henry Ford Hospital, Detroit, MI, United States.
Clara HwangHenry Ford Cancer Institute, Henry Ford Hospital, Detroit, MI, United States.
Leslie A FecherUniversity of Michigan Rogel Cancer Center, Ann Arbor, MI, United States.
Cyndi Gonzalez GomezUniversity of Michigan Rogel Cancer Center, Ann Arbor, MI, United States.
Brandon Hayes-LattinDivision of Hematology and Medical Oncology, Knight Cancer Institute at Oregon Health and Science University, Portland, OR, United States.
Michael J GloverStanford Cancer Institute at Stanford University, Stanford, CA, United States.
Sumit A ShahStanford Cancer Institute at Stanford University, Stanford, CA, United States.
Dharmesh GopalakrishnanDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Elizabeth A GriffithsDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Daniel H KwonUCSF Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, United States.
Vadim S KoshkinUCSF Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, United States.
Sana MahmoodSidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States.
Babar BashirSidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States.
Taylor NonatoMoores Cancer Center, University of California San Diego, La Jolla, CA, United States.
Pedram RazaviMoores Cancer Center, University of California San Diego, La Jolla, CA, United States.
Rana R McKayMoores Cancer Center, University of California San Diego, La Jolla, CA, United States.
Gayathri NagarajDivision of Medical Oncology and Hematology, Loma Linda University, Loma Linda, CA, United States.
Eric OliginoCardio-Oncology, Hartford HealthCare Cancer, Hartford, CT, United States.
Matthew PucVirtua Health, Marlton, NJ, United States.
Polina TregubenkoThe University of Kansas Health System, Kansas City, KS, United States.
Elizabeth M Wulff-BurchfieldThe University of Kansas Health System, Kansas City, KS, United States.
Zhuoer XieMayo Clinic, Rochester, MN, United States.
Thorvardur R HalfdanarsonMayo Clinic, Rochester, MN, United States.
Dimitrios FarmakiotisBrown University and Lifespan Cancer Institute, Providence, RI, United States.
Elizabeth J KleinBrown University and Lifespan Cancer Institute, Providence, RI, United States.
Elizabeth V RobilottiMemorial Sloan-Kettering Cancer Center, New York, NY, United States.
Gregory J RielyMemorial Sloan-Kettering Cancer Center, New York, NY, United States.
Jean-Bernard DurandMD Anderson Cancer Center, Houston, TX, United States.
Salim S HayekDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, United States.
Lavanya KondapalliDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Stephanie BergLoyola University Medical Center, Chicago, IL, United States.
Timothy E O'ConnorLoyola University Medical Center, Chicago, IL, United States.
Mehmet A BilenWinship Cancer Institute of Emory University, Emory University, Atlanta, GA, United States.
Cecilia CastellanoWinship Cancer Institute of Emory University, Emory University, Atlanta, GA, United States.
Melissa K AccordinoHerbert Irving Comprehensive Cancer Center at Columbia University, New York, NY, United States.
Blau SibelNorthwest Medical Specialties, Tacoma, WA, United States.
Lisa B WeissmannMount Auburn Hospital, Cambridge, MA, United States.
Chinmay JaniMount Auburn Hospital, Cambridge, MA, United States.
Daniel B FloraSt. Elizabeth Healthcare, Edgewood, KY, United States.
Lawrence RudskiSegal Cancer Centre, Jewish General Hospital, McGill University, Montréal, QC, Canada.
Miriam Santos DutraSegal Cancer Centre, Jewish General Hospital, McGill University, Montréal, QC, Canada.
Bouganim NathanielMcGill University Health Centre, Montréal, QC, Canada.
Erika Ruíz-GarcíaInstituto Nacional de Cancerología, Mexico City, Mexico.
Diana Vilar-CompteInstituto Nacional de Cancerología, Mexico City, Mexico.
Shilpa GuptaCleveland Clinic, Cleveland, OH, United States.
Alicia MorgansDana-Farber Cancer Institute, Boston, MA, United States. Electronic address: aliciak_morgans@dcfi.harvard.edu.
Anju NohriaCardiovascular Division, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, MA, United States. Electronic address: anohria@bwh.harvard.edu.
COVID-19 and Cancer Consortium
Dana-Farber Cancer Institute · USVanderbilt University · USThe University of Texas MD Anderson Cancer Center · USUniversity of California San Diego · USUniversity of Cincinnati · USVanderbilt University Medical Center · USEmory University · USHenry Ford Hospital · USInstituto Nacional de Cancerología · MXJewish General Hospital · CALifespan · USLoyola University Medical Center · USMayo Clinic in Arizona · USMemorial Sloan Kettering Cancer Center · USMount Auburn Hospital · USRoswell Park Comprehensive Cancer Center · USThe University of Kansas Health System · USThomas Jefferson University · USUCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of Michigan · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jin Chen · 1995 to 2026
$172.8M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Christine B. Ambrosone · 1985 to 2026
$116.6M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000445NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA068485
6 · The paper itself

Abstract

Background: Data regarding outcomes among patients with cancer and co-morbid cardiovascular disease (CVD)/cardiovascular risk factors (CVRF) after SARS-CoV-2 infection are limited. Objectives: To compare Coronavirus disease 2019 (COVID-19) related complications among cancer patients with and without co-morbid CVD/CVRF. Methods: Retrospective cohort study of patients with cancer and laboratory-confirmed SARS-CoV-2, reported to the COVID-19 and Cancer Consortium (CCC19) registry from 03/17/2020 to 12/31/2021. CVD/CVRF was defined as established CVD Results: Among 10,876 SARS-CoV-2 infected patients with cancer (median age 65 [IQR 54-74] years, 53% female, 52% White), 6253 patients (57%) had co-morbid CVD/CVRF. Co-morbid CVD/CVRF was associated with higher COVID-19 severity (adjusted OR: 1.25 [95% CI 1.11-1.40]). Adverse CV events were significantly higher in patients with CVD/CVRF (all Conclusions: Co-morbid CVD/CVRF is associated with higher COVID-19 severity among patients with cancer, particularly those not receiving active cancer therapy. While infrequent, COVID-19 related CV complications were higher in patients with comorbid CVD/CVRF. (COVID-19 and Cancer Consortium Registry [CCC19]; NCT04354701).

Indexed as

CancerCardio-oncologyCardiovascular diseaseCOVID-19 outcomes

Identifiers

PMID37302348
PMCPMC10235676
OpenAlexW4379232573

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.