Evidence map›Paper›PMID 37302177›Full record

ArticleAdvances in biological regulation2023

A motif in the 5'untranslated region of messenger RNAs regulates protein synthesis in a S6 kinase-dependent manner.

Hyun-Chul Shin, Yury A Bochkov, Kangsan Kim, James E Gern, Nizar N Jarjour, Stephane Esnault

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in biological regulation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Evaluation of Eukaryotic mRNA Coding Potential.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Hyun-Chul ShinDepartment of Chemistry Education, Korea National University of Education, Cheongju-si, Chungcheonbuk-do, Republic of Korea.
Yury A BochkovDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Kangsan KimDepartment of Chemistry Education, Korea National University of Education, Cheongju-si, Chungcheonbuk-do, Republic of Korea.
James E GernDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA; Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Nizar N JarjourDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Stephane EsnaultDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. Electronic address: sesnault@wisc.edu.
University of Wisconsin–Madison · USKorea National University of Education · KR

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
Wisconsin Infant Study Cohort (WISC)U19AI104317 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern, CHRISTINE Marie SEROOGY · 2013 to 2026
$22.5M
Thr Role of Pin1 in AirwayP01HL088594 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2008 to 2017
$21.0M
Mechanisms of Enhanced Neutralizing Antibody Responses to Rhinovirus CR01AI148707 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BOCHKOV, YURY A · 2020 to 2024
$3.9M
NCATS NIH HHS UL1 TR002373NCRR NIH HHS UL1 RR025011NHLBI NIH HHS P01 HL088594NIAID NIH HHS R01 AI148707NIAID NIH HHS U19 AI104317
6 · The paper itself

Abstract

The 5' untranslated regions (UTRs) in messenger RNAs (mRNAs) play an important role in the regulation of protein synthesis. We had previously identified a group of mRNAs that includes human semaphorin 7A (SEMA7A) whose translation is upregulated by the Erk/p90S6K pathway in human eosinophils, with a potential negative impact in asthma and airway inflammation. In the current study, we aimed to find a common 5'UTR regulatory cis-element, and determine its impact on protein synthesis. We identified a common and conserved 5'UTR motif GGCTG-[(C/G)T(C/G)]

Indexed as

Protein Biosynthesis5' Untranslated RegionsHumansMutationRibosomal Protein S6 KinasesRNA, Messenger5' Untranslated RegionsRibosomal Protein S6 KinasesRNA, Messenger5′ untranslated regionEosinophilsmRNA translationProtein synthesisS6 kinase

Identifiers

PMID37302177
PMCPMC10735251
OpenAlexW4379795523

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.