ArticleScientific reports2023
Computational fluid dynamics simulation of two-phase flow patterns in a serpentine microfluidic device.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Diffusion-Controlled Nucleation, Growth, and Self-Assembly of Silica Nanoparticles in Laminar Microfluidic Flow.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- ML-automated microfluidic circuit design.Science advances · 2026Article
- Optimization of selective catalytic reduction for nox emission control: an experimental and CFD analysis of mixer designs.Scientific reports · 2025Article
- Numerical simulation and experimental study of Inlet velocity on oil water separation effect by a fixed hydrocyclone.Scientific reports · 2025Article
- Simulation and experimental study of shell-kernel separation device for household sunflower based on CFD-DEM coupling.Scientific reports · 2025Article
- Solvent extraction of Ac-225 in nano-layer coated, solvent resistant PDMS microfluidic chips.Scientific reports · 2024Article
- The impact of 180° return bend inclination on pressure drop characteristics and phase distribution during oil-water flow.Heliyon · 2024Article
- Design and Fabrication of a 3D-Printed Microfluidic Immunoarray for Ultrasensitive Multiplexed Protein Detection.Micromachines · 2023Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the current research work, the flow behavior of a liquid-liquid extraction (LLE) process in a serpentine microchannel was analyzed. The simulation was performed using a 3D model and the results were found to be consistent with experimental data. The impact of the flow of chloroform and water on the flow model was also examined. The data indicate that once the aqua and organic phases flow rates are low and similar, a slug flow pattern is observed. However, as the overall flow rate raises, the slug flow transforms into parallel plug flow or droplet flow. An increment in the aqua flows while maintaining a constant organic phase flow rate results in a transition from slug flow to either droplet flow or plug flow. Finally, the patterns of flow rate in the serpentine micro-channel were characterized and depicted. The results of this study will provide valuable insights into the behavior of two-phase flow patterns in serpentine microfluidic devices. This information can be used to optimize the design of microfluidic devices for various applications. Furthermore, the study will demonstrate the applicability of CFD simulation in investigating the behavior of fluids in microfluidic devices, which can be a cost-effective and efficient alternative to experimental studies.
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