Evidence map›Paper›PMID 37301760›Full record

ArticleJournal of the American Heart Association2023

Clinical Outcomes in High-Gradient, Classical Low-Flow, Low-Gradient, and Paradoxical Low-Flow, Low-Gradient Aortic Stenosis After Transcatheter Aortic Valve Implantation: A Report From the SwissTAVI Registry.

Max Wagener, Oliver Reuthebuch, Dik Heg, David Tüller, Enrico Ferrari, Jürg Grünenfelder, Christoph Huber, Igal Moarof, Olivier Muller, Fabian Nietlispach and 9 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Time- and dose-dependent high-sensitivity cardiac troponin-T to improve outcome prediction after TAVI: a multicenter cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  5. Article
  6. Balloon-Expandable Versus Self-Expanding Valves in Low-Flow, Low-Gradient Aortic Stenosis: Does Valve Type Matter?Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Early Stroke Volume Variation After Transcatheter or Surgical Aortic Valve Replacement Predicts Clinical Outcomes in Low-Flow Aortic Stenosis.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Observational
  16. Impact of cardiovascular comorbidities on echocardiographic parameters in aortic stenosis.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Transcatheter Aortic Valve Implantation in Very Low-Gradient Aortic Stenosis.Structural heart : the journal of the Heart Team · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 2 countries.

Max WagenerUniversity Hospital Basel, University of Basel Switzerland.ORCID 0000-0002-7970-8989
Oliver ReuthebuchUniversity Hospital Basel, University of Basel Switzerland.ORCID 0000-0003-1386-0686
Dik HegCTU Bern, University of Bern Switzerland.ORCID 0000-0002-8766-7945
David TüllerTriemli Hospital Zürich Zürich Switzerland.
Enrico FerrariCardiocentro Ticino Lugano Switzerland.ORCID 0000-0002-2837-3242
Jürg GrünenfelderHirslanden Hospital Zürich Zürich Switzerland.ORCID 0009-0001-7796-8517
Christoph HuberUniversity Hospital Geneva, University of Geneva Switzerland.ORCID 0000-0001-9048-849X
Igal MoarofHirslanden Hospital Aarau Aarau Switzerland.
Olivier MullerUniversity Hospital Lausanne, University of Lausanne Switzerland.
Fabian NietlispachCardiovascular Center Zürich, Hirslanden Klinik Im Park Zürich Switzerland.
Stéphane NobleUniversity Hospital Geneva, University of Geneva Switzerland.ORCID 0000-0002-8018-2857
Marco RoffiUniversity Hospital Geneva, University of Geneva Switzerland.ORCID 0000-0002-3051-0170
Maurizio TaramassoHirslanden Hospital Zürich Zürich Switzerland.
Christian TemplinUniversity Hospital Zürich, University of Zürich Switzerland.ORCID 0000-0003-0287-4193
Stefan ToggweilerCantonal Hospital Luzern Switzerland.ORCID 0000-0002-7860-0298
Peter WenaweserHirslanden Hospital Zürich Zürich Switzerland.
Stephan WindeckerDepartment of Cardiology Inselspital, Bern University Hospital, University of Bern Bern Switzerland.ORCID 0000-0003-2653-6762
Stefan StorteckyDepartment of Cardiology Inselspital, Bern University Hospital, University of Bern Bern Switzerland.ORCID 0000-0002-5076-0177
Raban JegerUniversity Hospital Basel, University of Basel Switzerland.ORCID 0000-0003-1290-5491
Klinik Hirslanden · CHUniversity of Basel · CHUniversity of Bern · CHUniversity of Geneva · CHEpatocentro Ticino · CHHirslanden Klinik Aarau · CHHirslanden Klinik Im Park · CHLuzerner Kantonsspital · CHTriemli Hospital · CHUniversity of Lausanne · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background In view of the rising global burden of severe symptomatic aortic stenosis, its early recognition and treatment is key. Although patients with classical low-flow, low-gradient (C-LFLG) aortic stenosis have higher rates of death after transcatheter aortic valve implantation (TAVI) when compared with patients with high-gradient (HG) aortic stenosis, there is conflicting evidence on the death rate in patients with severe paradoxical low-flow, low-gradient (P-LFLG) aortic stenosis. Therefore, we aimed to compare outcomes in real-world patients with severe HG, C-LFLG, and P-LFLG aortic stenosis undergoing TAVI. Methods and Results Clinical outcomes up to 5 years were addressed in the 3 groups of patients enrolled in the prospective, national, multicenter SwissTAVI registry. A total of 8914 patients undergoing TAVI at 15 heart valve centers in Switzerland were analyzed for the purpose of this study. We observed a significant difference in time to death at 1 year after TAVI, with the lowest observed in HG (8.8%) aortic stenosis, followed by P-LFLG (11.5%; hazard ratio [HR], 1.35 [95% CI, 1.16-1.56];

Indexed as

Aortic Valve StenosisTranscatheter Aortic Valve ReplacementAortic ValveHumansProspective StudiesRegistriesRetrospective StudiesSeverity of Illness IndexTreatment Outcomelow‐flow, low‐gradientoutcomes in aortic stenosisSwissTAVItranscatheter aortic valve implantationvalvular heart disease

Identifiers

PMID37301760
PMCPMC10356021
OpenAlexW4380203899

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.