SynthesisJournal of the American Heart Association2023
Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta-Analysis of 20 Prospective Studies.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- First-Line Dapagliflozin, Metformin, or Combination Therapy in Type 2 Diabetes: Vascular and Molecular Outcomes of a Randomised Controlled Trial.Diabetes, obesity & metabolism · 2026Trial
- The Impact of Cocoa Flavanols in Modulating Resting Cerebral Blood Flow During Prolonged Sitting in Healthy Young and Older Adults.Nutrients · 2025Trial
- Carotid plaque burden across the glycaemic spectrum: a cross-sectional study.BMC endocrine disorders · 2026Article
- Different Metabolic Phenotypes of Obesity and 2 Decades Risk of Cardio-Renal-Metabolic Multimorbidity: Tehran Lipid and Glucose Study.Journal of the American Heart Association · 2025Article
- Role of Arterial Stiffness and Carotid Intima-Media Thickness on Subclinical Atherosclerosis and Cardiovascular Risk Assessment.Cardiology and therapy · 2025Review
- Associations between carotid artery intima-media thickness, traditional risk factors and proteins.NPJ cardiovascular health · 2025Article
- Carotid wall structure during and after 6 months of spaceflight.Frontiers in physiology · 2025Article
- Measuring arterial tortuosity in the cerebrovascular system using Time-of-Flight MRI.medRxiv : the preprint server for health sciences · 2024Article
- Carotid Intima-Media Thickness in Surgically or Conservatively Managed Patients With Primary Hyperparathyroidism.The Journal of clinical endocrinology and metabolism · 2024Article
- Novel imaging modalities for the identification of vulnerable plaques.Frontiers in cardiovascular medicine · 2024Review
- Plasma proteomics and carotid intima-media thickness in the UK biobank cohort.Frontiers in cardiovascular medicine · 2024Article
- Intima-media thickness at the near or far wall of the common carotid artery in cardiovascular risk assessment.European heart journal open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
64 authors at 20 institutions in 20 countries.
Lena TschidererInstitute of Health Economics Medical University of Innsbruck Innsbruck Austria.ORCID 0000-0001-7988-853X
Lisa SeekircherInstitute of Health Economics Medical University of Innsbruck Innsbruck Austria.ORCID 0000-0003-0260-3262
Raffaele IzzoDepartment of Advanced Biomedical Sciences Federico II University Naples Italy.ORCID 0000-0002-0308-2836
Costantino MancusiDepartment of Advanced Biomedical Sciences Federico II University Naples Italy.ORCID 0000-0001-6690-1408
Maria V ManziDepartment of Advanced Biomedical Sciences Federico II University Naples Italy.ORCID 0000-0002-1979-7131
Damiano BaldassarreDepartment of Medical Biotechnology and Translational Medicine University of Milan Milan Italy.ORCID 0000-0002-2766-8882
Mauro AmatoCentro Cardiologico Monzino Stituto di Ricovero e Cura a Carattere Scientifico Milan Italy.ORCID 0000-0002-0118-5719
Elena TremoliMaria Cecilia Hospital Cotignola (Ravenna) Italy.ORCID 0000-0002-0929-6106
Fabrizio VegliaMaria Cecilia Hospital Cotignola (Ravenna) Italy.ORCID 0000-0002-9378-8874
Tomi-Pekka TuomainenInstitute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland.
Jussi KauhanenInstitute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland.
Ari VoutilainenInstitute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland.ORCID 0000-0002-0664-2675
Bernhard IglsederDepartment of Geriatric Medicine Gemeinnützige Salzburger Landeskliniken Betriebsgesellschaft GmbH Christian-Doppler-Klinik Salzburg Austria.ORCID 0000-0002-6132-8670
Lars LindDepartment of Medicine Uppsala University Uppsala Sweden.ORCID 0000-0003-2335-8542
Tatjana RundekDepartment of Neurology University of Miami Miller School of Medicine Miami FL.ORCID 0000-0002-7115-9815
Moise DesvarieuxDepartment of Epidemiology, Mailman School of Public Health Columbia University New York NY.
Akihiko KatoBlood Purification Unit Hamamatsu University Hospital Hamamatsu Japan.
Eric de GrootImagelabonline and Cardiovascular Erichem the Netherlands.ORCID 0000-0003-1230-9083
Gülay AşçiNephrology Department Ege University School of Medicine Bornova-Izmir Turkey.ORCID 0000-0001-5582-6430
Ercan OkNephrology Department Ege University School of Medicine Bornova-Izmir Turkey.ORCID 0000-0002-0669-4037
Stefan AgewallDepartment of Clinical Sciences, Danderyd Hospital Division of Cardiology Karolinska Institutet Stockholm Sweden.
Joline W J BeulensDepartment of Epidemiology and Data Science, Amsterdam University Medical Center-Location Vrije Universiteit Medical Center Amsterdam the Netherlands.ORCID 0000-0002-4181-0937
Christopher D ByrneSchool of Human Development and Health, Faculty of Medicine University of Southampton Southampton UK.ORCID 0000-0001-6322-7753
Philip C CalderSchool of Human Development and Health, Faculty of Medicine University of Southampton Southampton UK.ORCID 0000-0002-6038-710X
Hertzel C GersteinDepartment of Medicine and Population Health Research Institute McMaster University Hamilton Ontario Canada.ORCID 0000-0001-8072-2836
Paolo GreseleDivision of Internal and Cardiovascular Medicine, Department of Medicine and Surgery University of Perugia Perugia Italy.ORCID 0000-0001-5365-8445
Gerhard KlingenschmidDepartment of Neurology Medical University of Innsbruck Innsbruck Austria.
Michiaki NagaiDepartment of Internal Medicine General Medicine and Cardiology, Hiroshima City Asa Hospital Hiroshima Japan.
Michael H OlsenDepartment of Internal Medicine, Holbaek Hospital University of Southern Denmark Odense Denmark.ORCID 0000-0003-2230-5780
Grace ParragaDepartment of Medical Biophysics, Robarts Research Institute Western University London ON Canada.ORCID 0000-0002-5619-4145
Maya S SafarovaDepartment of Cardiovascular Medicine University of Kansas Medical Center Kansas City KS.ORCID 0000-0003-3069-3752
Naveed SattarBritish Heart Foundation Glasgow Cardiovascular Research Centre University of Glasgow Glasgow UK.ORCID 0000-0002-1604-2593
Michael SkiltonCharles Perkins Centre, Faculty of Medicine and Health University of Sydney Sydney NSW Australia.ORCID 0000-0003-2793-2388
Coen D A StehouwerDepartment of Internal Medicine and Cardiovascular Research Institute Maastricht Maastricht University Medical Centre Maastricht the Netherlands.ORCID 0000-0001-8752-3223
Heiko UthoffDepartment of Angiology University Hospital Basel Basel Switzerland.ORCID 0000-0003-4787-5659
Michiel A van AgtmaelDepartment of Internal Medicine Amsterdam University Medical Center, Vrije Universiteit Amsterdam the Netherlands.ORCID 0000-0002-7966-6934
Amber A van der HeijdenDepartment of General Practice, Amsterdam University Medical Center-Location Vrije Universiteit Medical Center Amsterdam the Netherlands.
Dorota A Zozulińska-ZiółkiewiczDepartment of Internal Medicine and Diabetology Poznan University of Medical Sciences Poznan Poland.ORCID 0000-0003-2995-9971
Hyun-Woong ParkDivision of Cardiology, Department of Internal Medicine Chungnam National University Sejong Hospital Sejong-si South Korea.
Moo-Sik LeeDepartment of Preventive Medicine, College of Medicine Konyang University Daejeon South Korea.
Jang-Ho BaeHeart Center, Konyang University Hospital Daejeon South Korea.ORCID 0000-0001-9533-7527
Oscar BeloquiDepartment of Internal Medicine University Clinic of Navarra Navarra Spain.
Manuel F LandechoDepartment of Internal Medicine University Clinic of Navarra Navarra Spain.ORCID 0000-0003-3234-8805
Matthieu PlichartParis Cardiovascular Research Centre University Paris Descartes Paris France.ORCID 0009-0007-4134-9339
Pierre DucimetiereFaculty of Medicine University Paris Descartes Paris France.
Jean Philippe EmpanaParis Cardiovascular Research Centre University Paris Descartes Paris France.ORCID 0000-0002-1469-7772
Lena BokemarkWallenberg Laboratory for Cardiovascular Research University of Gothenburg Gothenburg Sweden.
Göran BergströmDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.ORCID 0000-0003-4289-5722
Caroline SchmidtWallenberg Laboratory for Cardiovascular Research University of Gothenburg Gothenburg Sweden.ORCID 0000-0001-8534-3237
Samuela CastelnuovoCentro Dislipidemie, Aziende Socio Sanitarie Territoriali Grande Ospedale Metropolitano Niguarda Milan Italy.ORCID 0009-0002-9230-0141
Laura CalabresiDepartment of Pharmacological and Biomolecular Sciences University of Milan Milan Italy.
Giuseppe D NorataDepartment of Pharmacological and Biomolecular Sciences University of Milan Milan Italy.ORCID 0000-0002-6081-1257
Liliana GrigoreStituto di Ricovero e Cura a Carattere Scientifico Multimedica Milan Italy.
Alberico CatapanoDepartment of Pharmacological and Biomolecular Sciences University of Milan Milan Italy.ORCID 0000-0002-7593-2094
Dong ZhaoDepartment of Epidemiology, Beijing Anzhen Hospital Capital Medical University Beijing China.ORCID 0000-0002-3239-3449
Miao WangDepartment of Epidemiology, Beijing Anzhen Hospital Capital Medical University Beijing China.
Jing LiuDepartment of Epidemiology, Beijing Anzhen Hospital Capital Medical University Beijing China.ORCID 0000-0002-3311-0818
M Arfan IkramDepartment of Epidemiology Erasmus University Medical Center Rotterdam the Netherlands.ORCID 0000-0003-0372-8585
Maryam KavousiDepartment of Epidemiology Erasmus University Medical Center Rotterdam the Netherlands.ORCID 0000-0001-5976-6519
Michiel L BotsJulius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht the Netherlands.ORCID 0000-0003-2871-9810
Michael J SweetingDepartment of Health Sciences University of Leicester Leicester UK.ORCID 0000-0003-0980-8965
Matthias W LorenzKlinik für Neurologie Krankenhaus Nordwest Frankfurt am Main Germany.ORCID 0000-0002-7565-1751
Peter WilleitInstitute of Health Economics Medical University of Innsbruck Innsbruck Austria.ORCID 0000-0002-1866-7159
Proof‐ATHERO Study Group
Innsbruck Medical University · ATUniversity of Milan · ITCapital Medical University · CNFederico II University Hospital · ITUniversity of Eastern Finland · FIAmsterdam University Medical Centers · NLClinica Universidad de Navarra · ESEge University · TRErasmus MC · NLKonyang University · KRMaria Cecilia Hospital · ITUniversité Paris Cité · FRUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Gothenburg · SEAzienda Socio Sanitaria Territoriale Lariana · ITBritish Heart Foundation · GBCentro Cardiologico Monzino · ITChungnam National University · KRDélégation Paris 5 · FRGoethe University Frankfurt · DE
Funding
NOVEL FACTORS FOR UNEXPLAINED PHENOTYPES OF SUBCLINICAL CAROTID ATHEROSCLEROSISR01NS065114 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BLANTON, SUSAN HALLORAN, RUNDEK, TATJANA · 2010 to 2014
$1.7MGenetics Determinants of Extreme Phenotypes of Subclinical AtherosclerosisK24NS062737 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RUNDEK, TATJANA · 2009 to 2013
$975kVascular Determinants of Dementia and Cognitive Decline in a Tri-Ethnic RegionR56NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, RUNDEK, TATJANA · 2021 to 2021
$537kNINDS NIH HHS K24 NS062737NINDS NIH HHS R01 NS065114NINDS NIH HHS R56 NS029993
Abstract
Background The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50;
Indexed as
Carotid Artery DiseasesPlaque, AtheroscleroticCarotid Artery, CommonCarotid Intima-Media ThicknessFemaleHumansMaleMiddle AgedProspective StudiesRisk Factorscarotid intima‐media thicknesscarotid plaqueindividual participant data meta‐analysisprospective studies
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.