ArticleJournal of the American Heart Association2023
Identifying Patients at High Risk of Left Atrial Appendage Thrombus Before Cardioversion: The CLOTS-AF Score.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Comparing Effectiveness and Safety of Left Atrial Appendage Closure Devices: A Network Meta-Analysis of Randomized Controlled Trials.Clinical cardiology · 2025Pooled it
- Echocardiography-based multimodal models for thromboembolic risk prediction in atrial fibrillation: a narrative review.Journal of thoracic disease · 2026Review
- Surgical Ablation of Atrial Fibrillation Using the Left Atrial Roof Approach.Journal of chest surgery · 2026Article
- De-risking Atrial Fibrillation: Refining Anticoagulation Decision-Making.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Review
- Left Atrial Appendage Thrombus and Dense Spontaneous Echo Contrast in Anticoagulated Atrial Fibrillation Patients Referred for Cardioversion: Beyond CHAJournal of clinical medicine · 2026Article
- Development of a nomogram with machine learning-assisted feature selection for predicting left atrial appendage thrombosis and severe spontaneous echo contrast in patients with non-paroxysmal atrial fibrillation.BMC cardiovascular disorders · 2026Article
- Transthoracic signs of left atrial cardiomyopathy predict presence of left atrial thromboembolic substrate.Heart rhythm O2 · 2026Article
- Article
- Intracardiac thrombus formations despite continuous oral anticoagulation in atrial fibrillation patients undergoing catheter ablation procedures: pilot development of a machine learning prediction model.Frontiers in cardiovascular medicine · 2026Article
- Can transesophageal echocardiography be safely deferred? A low-cost predictive model using D-dimer to exclude left atrial thrombus in treatment-naïve rheumatic mitral stenosis.Frontiers in cardiovascular medicine · 2026Article
- Epicardial Fat Tissue Volume Within 1 mm of the Left Atrium Combined With Left Atrial Appendage Volume is Associated With Thrombus in Nonvalvular Atrial Fibrillation: A CCTA-Based Risk Stratification Model.Cardiology research and practice · 2026Article
- Development and validation of interpretable machine learning models for predicting stroke in NVAF patients with CHAFrontiers in cardiovascular medicine · 2026Article
- A new risk-stratified scoring system for predicting left atrial appendage thrombus in patients with nonvalvular atrial fibrillation.BMC cardiovascular disorders · 2025Article
- External validation of CLOTS-AF score in patients with atrial fibrillation undergoing transesophageal echocardiography.Annals of medicine · 2025Article
- Prediction of spontaneous echo contrast following mitral valve transcatheter edge-to-edge repair.International journal of cardiology. Heart & vasculature · 2025Article
- Article
- Digital twin integrating clinical, morphological and hemodynamic data to identify stroke risk factors.NPJ digital medicine · 2025Article
- Spontaneous echo contrast in the left atrial appendage is linked to a higher risk of thromboembolic events and mortality in patients with atrial fibrillation.International journal of cardiology. Heart & vasculature · 2025Article
- Echocardiographic assessment of left atrial appendage morphology and function-an expert proposal by the German Working Group of Cardiovascular Ultrasound.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Review
- Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Transesophageal echocardiography-guided direct cardioversion is recommended in patients who are inadequately anticoagulated due to perceived risk of left atrial appendage thrombus (LAAT); however, LAAT risk factors remain poorly defined. Methods and Results We evaluated clinical and transthoracic echocardiographic parameters to predict LAAT risk in consecutive patients with atrial fibrillation (AF)/atrial flutter undergoing transesophageal echocardiography before cardioversion between 2002 and 2022. Regression analysis identified predictors of LAAT, combined to create the novel CLOTS-AF risk score (comprising clinical and echocardiographic LAAT predictors), which was developed in the derivation cohort (70%) and validated in the remaining 30%. A total of 1001 patients (mean age, 62±13 years; 25% women; left ventricular ejection fraction, 49.8±14%) underwent transesophageal echocardiography, with LAAT identified in 140 of 1001 patients (14%) and dense spontaneous echo contrast precluding cardioversion in a further 75 patients (7.5%). AF duration, AF rhythm, creatinine, stroke, diabetes, and echocardiographic parameters were univariate LAAT predictors; age, female sex, body mass index, anticoagulant type, and duration were not (all
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.