Evidence map›Paper›PMID 37301628›Full record

ArticleWilderness & environmental medicine2023

Alaska Backcountry Expeditionary Hunting Promotes Sustained Muscle Protein Synthesis.

Robert H Coker, Brent C Ruby, Melynda S Coker, Larry Bartlett, Brandon Kowalski, Anna V Goropashnaya, Terry Bateman, Mahalakshmi Shankaran, Marc Hellerstein, William J Evans

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Wilderness & environmental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Robert H CokerMontana Center for Work Physiology and Exercise Metabolism, University of Montana, Missoula, MT. Electronic address: robert.coker@umontana.edu.
Brent C RubyMontana Center for Work Physiology and Exercise Metabolism, University of Montana, Missoula, MT.
Melynda S CokerMontana Center for Work Physiology and Exercise Metabolism, University of Montana, Missoula, MT.
Larry BartlettPristine Ventures, Inc, Fairbanks, AK.
Brandon KowalskiDepartment of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK.
Anna V GoropashnayaInstitute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK.
Terry BatemanDepartment of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK.
Mahalakshmi ShankaranDepartment of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA.
Marc HellersteinDepartment of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA.
William J EvansDepartment of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA.
University of Alaska Fairbanks · USUniversity of California, Berkeley · USUniversity of Montana · US

Funding

The Administrative CoreP20GM103395 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI BRIAN M BARNES · 2012 to 2026
$66.1M
Renovation of LARS for Arctic Ground Squirrel BreedingP20GM130443 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI KELLY L DREW · 2019 to 2026
$16.4M
NIGMS NIH HHS P20 GM103395NIGMS NIH HHS P20 GM130443
6 · The paper itself

Abstract

introductionWe have previously described negative energy balance (ie, -9.7±3.4 MJ/d) and weight loss (Δ-1.5 ± 0.7 kg) influenced by high levels of energy expenditure (ie, 17.4±2.6 MJ/d) during remote expeditionary hunting in Alaska. Despite negative energy balance, participants retained skeletal muscle. The purpose of this pilot study was to measure skeletal muscle protein synthesis and examine molecular markers of skeletal muscle protein metabolism under similar conditions of physical and nutrient stress.

methodsThe "virtual biopsy method" was used to evaluate integrated fractional synthetic rates (FSRs) of muscle protein from blood samples in 4 participants. Muscle biopsies were taken to measure molecular markers of muscle protein kinetics (ie, FSTL1, MEF2, MYOD1, B2M, and miR-1-3p, -206, -208b, 23a, and 499a) using real-time polymerase chain reaction.

resultsOur findings in 4 participants (2 females [28 and 62 y of age; 66.2 and 71.8 kg body weight; 25.5 and 26.7 kg/m

conclusionsPreservation of skeletal muscle under conditions of physical and nutrient stress seems to be supported by positive inflection of skeletal muscle FSR and molecular activation.

Indexed as

Follistatin-Related ProteinsMuscle ProteinsAlaskaBody WeightEnergy MetabolismFemaleHumansHuntingMaleMuscle, SkeletalPilot ProjectsFollistatin-Related ProteinsFSTL1 protein, humanMuscle Proteinscaloric balanceenergy expendituremusculoskeletalphysical activity

Identifiers

PMID37301628
PMCPMC10526753
OpenAlexW4380052334

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.