Evidence map›Paper›PMID 37301612›Full record

ArticleSurgery2023

Impact of liver cirrhosis, the severity of cirrhosis, and portal hypertension on the outcomes of minimally invasive left lateral sectionectomies for primary liver malignancies.

Fabricio Ferreira Coelho, Paulo Herman, Jaime A P Kruger, Andrew G R Wu, Ken-Min Chin, Kiyoshi Hasegawa, Wanguang Zhang, Mohammad Alzoubi, Davit L Aghayan, Tiing-Foong Siow and 60 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Impact of liver cirrhosis, severity of cirrhosis and portal hypertension on the difficulty of laparoscopic and robotic minor liver resections for primary liver malignancies in the anterolateral segments.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2024
    Article
  6. Modern surgical approach to hepatocellular carcinoma.Hepatobiliary surgery and nutrition · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

70 authors at 20 institutions in 18 countries.

Fabricio Ferreira CoelhoDepartment of Gastroenterology, Liver Surgery Unit, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Paulo HermanDepartment of Gastroenterology, Liver Surgery Unit, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Jaime A P KrugerDepartment of Gastroenterology, Liver Surgery Unit, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Andrew G R WuYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ken-Min ChinDepartment of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital and National Cancer Centre Singapore, Singapore.
Kiyoshi HasegawaHepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Wanguang ZhangHepatic Surgery Center and Hubei Key Laboratory of Hepato-Biliary-Pancreatic Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Mohammad AlzoubiDepartment of Surgery, Fondazione Poliambulanza, Brescia, Italy.
Davit L AghayanThe Intervention Centre and Department of HPB Surgery, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Tiing-Foong SiowDivision of General Surgery, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Olivier ScattonDepartment of Digestive, HBP and Liver Transplantation, Hopital Pitie-Salpetriere, Sorbonne Universite, Paris, France.
T Peter KinghamDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Marco V MarinoGeneral Surgery Department, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy and General Surgery Department, F Tappeiner Hospital, Merano, Italy.
Vincenzo MazzaferroHPB Surgery and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori di Milano and University of Milan, Italy.
Adrian K H ChiowHepatopancreatobiliary Unit, Department of Surgery, Changi General Hospital, Singapore.
Iswanto SucandyDigestive Health Institute, AdventHealth Tampa, Florida.
Arpad IvaneczDepartment of Abdominal and General Surgery, University Medical Center Maribor, Maribor, Slovenia.
Sung Hoon ChoiDepartment of General Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
Jae Hoon LeeDepartment of Surgery, Division of Hepato-Biliary and Pancreatic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Mikel GastacaHepatobiliary Surgery and Liver Transplantation Unit, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
Marco VivarelliHPB Surgery and Transplantation Unit, United Hospital of Ancona, Department of Experimental and Clinical Medicine Polytechnic University of Marche, Ancona, Italy.
Felice GiulianteHepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of the Sacred Heart, Rome, Italy.
Andrea RuzzenenteGeneral and Hepatobiliary Surgery, Department of Surgery, Dentistry, Gynecology and Pediatrics University of Verona, GB Rossi Hospital, Verona, Italy.
Chee-Chien YongDepartment of Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Safi DokmakDepartment of HPB Surgery and Liver Transplantation, Beaujon Hospital, University Paris Cite, Clichy, France.
Constantino FondevilaGeneral and Digestive Surgery, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain and General and Digestive Surgery, Hospital Universitario La Paz, IdiPAZ, CIBERehd, Madrid, Spain.
Mikhail EfanovDepartment of Hepato-Pancreato-Biliary Surgery, Moscow Clinical Scientific Center, Moscow, Russia.
Zenichi MoriseDepartment of Surgery, Okazaki Medical Center, Fujita Health University School of Medicine, Okazaki, Japan.
Fabrizio Di BenedettoHPB Surgery and Liver Transplant Unit, University of Modena and Reggio Emilia, Modena, Italy.
Raffaele BrustiaDepartment of Digestive and Hepatobiliary and Pancreatic Surgery, AP-HP, Henri-Mondor Hospital, Creteil, France.
Raffaele Dalla ValleHepatobiliary Surgery Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Ugo BoggiDivision of General and Transplant Surgery, University of Pisa, Pisa, Italy.
David GellerDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, University of Pittsburgh Medical Center, PA, USA.
Andrea BelliDepartment of Abdominal Oncology, Division of Hepatopancreatobiliary Surgical Oncology, National Cancer Center-IRCCS-G. Pascale, Naples, Italy.
Riccardo MemeoUnit of Hepato-Pancreatc-Biliary Surgery, "F. Miulli" General Regional Hospital, Acquaviva delle Fonti, Bari, Italy.
Salvatore GruttadauriaDepartment for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS-ISMETT), University of Pittsburgh Medical Center Italy, Palermo, Italy; Department of General Surgery and Medical Surgical Specialties, University of Catania, Italy.
Alejandro MejiaThe Liver Institute, Methodist Dallas Medical Center, TX.
James O ParkDepartment of Surgery, University of Washington Medical Center, Seattle, WA.
Fernando RotellarHPB and Liver Transplant Unit, Department of General Surgery, Clinica Universidad de Navarra, Universidad de Navarra, Pamplona, Spain & Institute of Health Research of Navarra (IdisNA), Pamplona, Spain.
Gi Hong ChoiDivision of Hepatopancreatobiliary Surgery, Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Ricardo Robles-CamposDepartment of General, Visceral and Transplantation Surgery, Clinic and University Hospital Virgen de la Arrixaca, IMIB-ARRIXACA, El Palmar, Murcia, Spain.
Xiaoying WangDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Robert P SutcliffeDepartment of Hepatopancreatobiliary and Liver Transplant Surgery, University Hospitals Birmingham NHS Foundation Trust, United Kingdom.
Johann PratschkeDepartment of Surgery, Campus Charité Mitte and Campus Virchow-Klinikum, Charité-Universitätsmedizin, Corporate Member of Freie Universität Berlin, and Berlin Institute of Health, Berlin, Germany.
Eric C H LaiDepartment of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China.
Charing C N ChongDepartment of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, New Territories, China.
Mathieu D'HondtDepartment of Digestive and Hepatobiliary/Pancreatic Surgery, Groeninge Hospital, Kortrijk, Belgium.
Kazuteru MondenDepartment of Surgery, Fukuyama City Hospital, Hiroshima, Japan.
Santiago Lopez-BenHepatobiliary and Pancreatic Surgery Unit, Department of Surgery, Dr. Josep Trueta Hospital, IdIBGi, Girona, Spain.
Rong LiuFaculty of Hepatopancreatobiliary Surgery, the First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Alessandro FerreroDepartment of General and Oncological Surgery, Mauriziano Hospital, Turin, Italy.
Giuseppe Maria EttorreDivision of General Surgery and Liver Transplantation, San Camillo Forlanini Hospital, Rome, Italy.
Federica CiprianiHepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milan, Italy.
Daniel CherquiDepartment of Hepatobiliary Surgery, Assistance Publique Hopitaux de Paris, Centre Hepato-Biliaire, Paul-Brousse Hospital, Villejuif, France.
Xiao LiangDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Olivier SoubraneDepartment of Digestive, Oncologic and Metabolic Surgery, Institute Mutualiste Montsouris, Universite Paris Descartes, Paris, France.
Go WakabayashiCenter for Advanced Treatment of Hepatobiliary and Pancreatic Diseases, Ageo Central General Hospital, Saitama, Japan.
Roberto I TroisiDepartment of Clinical Medicine and Surgery, Division of HPB, Minimally Invasive and Robotic Surgery, Federico II University Hospital, Naples, Italy.
Mengqiu YinDepartment of Hepatobiliary Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Tan-To CheungDepartment of Surgery, Queen Mary Hospital, The University of Hong Kong, China.
Atsushi SugiokaDepartment of Surgery, Fujita Health University School of Medicine, Aichi, Japan.
Ho-Seong HanDepartment of Surgery, Seoul National University Hospital Bundang, Seoul National University College of Medicine, Seoul, Korea.
Tran Cong Duy LongDepartment of Hepatopancreatobiliary Surgery, University Medical Center, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
David FuksDepartment of Digestive, Oncologic and Metabolic Surgery, Institute Mutualiste Montsouris, Universite Paris Descartes, Paris, France.
Mohammad Abu HilalDepartment of Surgery, Fondazione Poliambulanza, Brescia, Italy; Department of Surgery, University Hospital Southampton, Southampton, United Kingdom.
Kuo-Hsin ChenDivision of General Surgery, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Luca AldrighettiHepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milan, Italy.
Bjørn EdwinThe Intervention Centre and Department of HPB Surgery, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Brian K P GohDepartment of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital and National Cancer Centre Singapore, Singapore; Duke National University of Singapore Medical School, Singapore. Electronic address: bsgkp@hotmail.com.
International Robotic and Laparoscopic Liver Resection study group investigators are coauthors of this study
Far Eastern Memorial Hospital · TWUlsan College · KRUniversidade de São Paulo · BRA. O. Ordine Mauriziano di Torino · ITAssistance Publique – Hôpitaux de Paris · FRCarlo Forlanini Hospital · ITChinese PLA General Hospital · CNFederico II University Hospital · ITFujita Health University · JPMarche Polytechnic University · ITNational University of Singapore · SGOslo University Hospital · NOPamela Youde Nethersole Eastern Hospital · CNUniversité Paris Cité · FRUniversity of Parma · ITUniversity of the Basque Country · ESVita-Salute San Raffaele University · ITAdventHealth Tampa · USAZ Groeninge · BEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundThe impact of cirrhosis and portal hypertension on perioperative outcomes of minimally invasive left lateral sectionectomies remains unclear. We aimed to compare the perioperative outcomes between patients with preserved and compromised liver function (noncirrhotics versus Child-Pugh A) when undergoing minimally invasive left lateral sectionectomies. In addition, we aimed to determine if the extent of cirrhosis (Child-Pugh A versus B) and the presence of portal hypertension had a significant impact on perioperative outcomes.

methodsThis was an international multicenter retrospective analysis of 1,526 patients who underwent minimally invasive left lateral sectionectomies for primary liver malignancies at 60 centers worldwide between 2004 and 2021. In the study, 1,370 patients met the inclusion criteria and formed the final study group. Baseline clinicopathological characteristics and perioperative outcomes of these patients were compared. To minimize confounding factors, 1:1 propensity score matching and coarsened exact matching were performed.

resultsThe study group comprised 559, 753, and 58 patients who did not have cirrhosis, Child-Pugh A, and Child-Pugh B cirrhosis, respectively. Six-hundred and thirty patients with cirrhosis had portal hypertension, and 170 did not. After propensity score matching and coarsened exact matching, Child-Pugh A patients with cirrhosis undergoing minimally invasive left lateral sectionectomies had longer operative time, higher intraoperative blood loss, higher transfusion rate, and longer hospital stay than patients without cirrhosis. The extent of cirrhosis did not significantly impact perioperative outcomes except for a longer duration of hospital stay.

conclusionLiver cirrhosis adversely affected the intraoperative technical difficulty and perioperative outcomes of minimally invasive left lateral sectionectomies.

Indexed as

Hypertension, PortalLiver NeoplasmsHepatectomyHumansLength of StayLiver CirrhosisRetrospective Studies

Identifiers

PMID37301612
PMCPMC10986843
OpenAlexW4380077734

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.