Evidence map›Paper›PMID 37301544›Full record

ArticleAging2023

Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing

Yutaro Kubota, Qinghong Han, Jose Reynoso, Yusuke Aoki, Noriyuki Masaki, Koya Obara, Kazuyuki Hamada, Michael Bouvet, Takuya Tsunoda, Robert M Hoffman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Methionine restriction and mimetics to ameliorate human aging and disease.Trends in endocrinology and metabolism: TEM · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yutaro KubotaAntiCancer Inc., San Diego, CA 92111, USA.
Qinghong HanAntiCancer Inc., San Diego, CA 92111, USA.
Jose ReynosoAntiCancer Inc., San Diego, CA 92111, USA.
Yusuke AokiAntiCancer Inc., San Diego, CA 92111, USA.
Noriyuki MasakiAntiCancer Inc., San Diego, CA 92111, USA.
Koya ObaraAntiCancer Inc., San Diego, CA 92111, USA.
Kazuyuki HamadaAntiCancer Inc., San Diego, CA 92111, USA.
Michael BouvetDepartment of Surgery, University of California, San Diego, CA 92111, USA.
Takuya TsunodaDepartment of Medical Oncology, Division of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Robert M HoffmanAntiCancer Inc., San Diego, CA 92111, USA.
University of California, San Diego · USAntiCancer (United States) · USShowa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity increases with aging. Methionine restriction affects lipid metabolism and can prevent obesity in mice. In the present study we observed C57BL/6 mice to double their body weight from 4 to 48 weeks of age and become obese. We evaluated the efficacy of oral administration of recombinant-methioninase (rMETase)-producing

Indexed as

Escherichia coliMethionineAdministration, OralAnimalsBody WeightCarbon-Sulfur LyasesDietMaleMiceMice, Inbred C57BLObesityRacemethionineRecombinant ProteinsCarbon-Sulfur LyasesL-methionine gamma-lyaseMethionineRacemethionineRecombinant ProteinsagingEscherichia colimethionine-deficient dietmethionine restrictionmicrobiomeobesityrecombinant methioninase (rMETase)weight-loss

Identifiers

PMID37301544
PMCPMC10292902
OpenAlexW4380089431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.