Evidence map›Paper›PMID 37301330›Full record

ReviewPharmacology & therapeutics2023

Noncoding RNA circuitry in melanoma onset, plasticity, and therapeutic response.

Katerina Grafanaki, Ioannis Grammatikakis, Arin Ghosh, Vishaka Gopalan, Gulden Olgun, Huaitian Liu, George C Kyriakopoulos, Ilias Skeparnias, Sophia Georgiou, Constantinos Stathopoulos and 4 more

Open access · greenAbstract readReview
In one paragraph

Review in Pharmacology & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. LncRNAEpigenetics · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Metabolic Reprogramming in Melanoma: An Epigenetic Point of View.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. International journal of nanomedicine · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Katerina GrafanakiLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Department of Dermatology, School of Medicine, University of Patras, 26504 Patras, Greece.
Ioannis GrammatikakisCancer Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Arin GhoshLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Vishaka GopalanCancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Gulden OlgunCancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Huaitian LiuLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
George C KyriakopoulosDepartment of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece.
Ilias SkeparniasLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Sophia GeorgiouDepartment of Dermatology, School of Medicine, University of Patras, 26504 Patras, Greece.
Constantinos StathopoulosDepartment of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece.
Sridhar HannenhalliCancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Glenn MerlinoLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Kerrie L MarieDivision of Molecular and Cellular Function, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Electronic address: kerrie.marie@manchester.ac.uk.
Chi-Ping DayLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: chi-ping.day@nih.gov.
National Cancer Institute · USNational Institutes of Health · USUniversity of Patras · GRCenter for Cancer Research · USNational Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of Manchester · GB

Funding

Genetically Engineered Mouse Models to Study RTK Function in MelanomaZIABC008756 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MERLINO, GLENN T. · 2009 to 2024
$17.7M
Intramural NIH HHS Z99 CA999999Wellcome TrustWellcome Trust 204796/Z/16/Z
6 · The paper itself

Abstract

Melanoma, the cancer of the melanocyte, is the deadliest form of skin cancer with an aggressive nature, propensity to metastasize and tendency to resist therapeutic intervention. Studies have identified that the re-emergence of developmental pathways in melanoma contributes to melanoma onset, plasticity, and therapeutic response. Notably, it is well known that noncoding RNAs play a critical role in the development and stress response of tissues. In this review, we focus on the noncoding RNAs, including microRNAs, long non-coding RNAs, circular RNAs, and other small RNAs, for their functions in developmental mechanisms and plasticity, which drive onset, progression, therapeutic response and resistance in melanoma. Going forward, elucidation of noncoding RNA-mediated mechanisms may provide insights that accelerate development of novel melanoma therapies.

Indexed as

MelanomaMicroRNAsRNA, Long NoncodingHumansRNA, CircularRNA, UntranslatedMicroRNAsRNA, CircularRNA, Long NoncodingRNA, UntranslatedCircular RNAs (circRNAs)Developmental stateLineageLong non-coding RNAs (lncRNAs)MelanomamicroRNAs (miRNAs)Non-coding RNAs (ncRNAs)PlasticityTranslational plasticity

Identifiers

PMID37301330
PMCPMC10527631
OpenAlexW4379880171

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.