ArticleJournal of affective disorders2023
Morphological abnormalities in youth with bipolar disorder and their relationship to clinical characteristics.
Article in Journal of affective disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Cortical Thickness in Middle and Older Aged Adults With Bipolar Disorder Across Six International Sites.Bipolar disorders · 2026Article
- Associations between negative symptoms and thermal pain perception in bipolar I disorder.International journal of bipolar disorders · 2025Article
- Neuroanatomical and Functional Correlates in Bipolar Disorder (BD): A Narrative Review.Journal of clinical medicine · 2025Review
- Machine learning-based assessment of morphometric abnormalities distinguishes bipolar disorder and major depressive disorder.Neuroradiology · 2025Article
- Understanding Pediatric Bipolar Disorder Through the Investigation of Clinical, Neuroanatomic, Neurophysiological and Neurocognitive Dimensions: A Pilot Study.Brain sciences · 2025Article
- From Connectivity to Controllability: Unraveling the Brain Biomarkers of Major Depressive Disorder.Brain sciences · 2024Article
- Innovative Neuroimaging Biomarker Distinction of Major Depressive Disorder and Bipolar Disorder through Structural Connectome Analysis and Machine Learning Models.Diagnostics (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo characterize the neuroanatomy of BD in youth and its correlation to clinical characteristics.
methodsThe current study includes a sample of 105 unmedicated youth with first-episode BD, aged between 10.1 and 17.9 years, and 61 healthy comparison adolescents, aged between 10.1 and 17.7 years, who were matched for age, race, sex, socioeconomic status, intelligence quotient (IQ), and education level. T1-weighted magnetic resonance imaging (MRI) images were obtained using a 4 T MRI scanner. Freesurfer (V6.0) was used to preprocess and parcellate the structural data, and 68 cortical and 12 subcortical regions were considered for statistical comparisons. The relationship between morphological deficits and clinical and demographic characteristics were evaluated using linear models.
resultsCompared with healthy youth, youth with BD had decreased cortical thickness in frontal, parietal, and anterior cingulate regions. These youth also showed decreased gray matter volumes in 6 of the 12 subcortical regions examined including thalamus, putamen, amygdala and caudate. In further subgroup analyses, we found that youth with BD with comorbid attention-deficit hyperactivity disorder (ADHD) or with psychotic symptoms had more significant deficits in subcortical gray matter volume. LIMITATIONS: We cannot provide information about the course of structural changes and impact of treatment and illness progression.
conclusionsOur findings indicate that youth with BD have significant neurostructural deficits in both cortical and subcortical regions mainly located in the regions related to emotion processing and regulation. Variability in clinical characteristics and comorbidities may contribute to the severity of anatomic alterations in this disorder.
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