Evidence map›Paper›PMID 37301267›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2023

Low-dose intrapulmonary drug delivery device for studies on next-generation therapeutics in mice.

Ana Maria Gracioso Martins, Douglas B Snider, Kristen D Popowski, Karl G Schuchard, Matias Tenorio, Sandip Akunuri, Junghyun Wee, Kara J Peters, Anton Jansson, Rohan Shirwaiker and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ana Maria Gracioso MartinsComparative Medicine Institute, North Carolina State University, Raleigh, NC, USA; Joint Department of Biomedical Engineering, North Carolina State University & University of North Carolina-Chapel Hill, NC, USA.
Douglas B SniderDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Comparative Medicine and Translational Research Training Program, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA.
Kristen D PopowskiDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA; Joint Department of Biomedical Engineering, North Carolina State University & University of North Carolina-Chapel Hill, NC, USA.
Karl G SchuchardComparative Medicine Institute, North Carolina State University, Raleigh, NC, USA; Edward P. Fitts Department of Industrial and Systems Engineering, North Carolina State University, Raleigh, NC, USA.
Matias TenorioJoint Department of Biomedical Engineering, North Carolina State University & University of North Carolina-Chapel Hill, NC, USA.
Sandip AkunuriJoint Department of Biomedical Engineering, North Carolina State University & University of North Carolina-Chapel Hill, NC, USA.
Junghyun WeeDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA.
Kara J PetersDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA.
Anton JanssonAnalytical Instrumentation Facility, Monteith Research Center, North Carolina State University, Raleigh, NC, USA.
Rohan ShirwaikerComparative Medicine Institute, North Carolina State University, Raleigh, NC, USA; Joint Department of Biomedical Engineering, North Carolina State University & University of North Carolina-Chapel Hill, NC, USA; Edward P. Fitts Department of Industrial and Systems Engineering, North Carolina State University, Raleigh, NC, USA; Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA.
Ke ChengDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA; Joint Department of Biomedical Engineering, North Carolina State University & University of North Carolina-Chapel Hill, NC, USA.
Donald O FreytesComparative Medicine Institute, North Carolina State University, Raleigh, NC, USA; Joint Department of Biomedical Engineering, North Carolina State University & University of North Carolina-Chapel Hill, NC, USA.
Glenn P CruseDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA. Electronic address: gpcruse@ncsu.edu.
North Carolina State University · US

Funding

Comparative Medicine and Translational Research Training ProgramT32OD011130 · OD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Lauren Virginia Schnabel · 2012 to 2026
$7.8M
NIH HHS T32 OD011130
6 · The paper itself

Abstract

Although nebulizers have been developed for delivery of small molecules in human patients, no tunable device has been purpose-built for targeted delivery of modern large molecule and temperature-sensitive therapeutics to mice. Mice are used most of all species in biomedical research and have the highest number of induced models for human-relevant diseases and transgene models. Regulatory approval of large molecule therapeutics, including antibody therapies and modified RNA highlight the need for quantifiable dose delivery in mice to model human delivery, proof-of-concept studies, efficacy, and dose-response. To this end, we developed and characterized a tunable nebulization system composed of an ultrasonic transducer equipped with a mesh nebulizer fitted with a silicone restrictor plate modification to control the nebulization rate. We have identified the elements of design that influence the most critical factors to targeted delivery to the deep lungs of BALB/c mice. By comparing an in silico model of the mouse lung with experimental data, we were able to optimize and confirm the targeted delivery of over 99% of the initial volume to the deep portions of the mouse lung. The resulting nebulizer system provides targeted lung delivery efficiency far exceeding conventional nebulizers preventing waste of expensive biologics and large molecules during proof-of-concept and pre-clinical experiments involving mice. (Word Count =207).

Indexed as

LungNebulizers and VaporizersAdministration, InhalationAerosolsAnimalsDrug Delivery SystemsEquipment DesignHumansMiceAerosolsControlled flowDelivery efficiencyLungMeshMouse

Identifiers

PMID37301267
PMCPMC10527740
OpenAlexW4380225139

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.