Evidence map›Paper›PMID 37301253›Full record

ArticleAnnals of vascular surgery2023

Type IV Hypersensitivity Reaction after Cyanoacrylate Venous Closure.

Leigh Ann A O'Banion, Michael Y Shao, Amna Ali, Mariya Kochubey, Yueqi Yan, Joshua Fallentine, Jae Hak Oh, Harik R Patel, Nishant Agrawal, Emely Carmona and 2 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of vascular surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Leigh Ann A O'BanionDivision of Vascular Surgery, Department of Surgery, University of California San Francisco-Fresno, Fresno, CA. Electronic address: Leighann.o'banion@ucsf.edu.
Michael Y ShaoDivision of Vascular Surgery, Northshore University Health System, Chicago, IL.
Amna AliDivision of Vascular Surgery, Department of Surgery, University of California San Francisco-Fresno, Fresno, CA.
Mariya KochubeyDivision of Vascular Surgery, Department of Surgery, University of California San Francisco-Fresno, Fresno, CA.
Yueqi YanUniversity of California Merced, Merced, CA.
Joshua FallentineGeorgetown University School of Medicine, Washington, DC.
Jae Hak OhGeorgetown University School of Medicine, Washington, DC.
Harik R PatelSt. George's University of London, London, UK.
Nishant AgrawalDivision of Vascular Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Emely CarmonaDivision of Vascular Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Eric S HagerDivision of Vascular Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Misaki M KiguchiDepartment of Vascular Surgery, MedStar Washington Hospital Center, Washington, DC.
University of California, San Francisco · USUniversity of Pittsburgh Medical Center · USGeorgetown University · USMedStar Washington Hospital Center · USNorthShore University HealthSystem · USSt George's, University of London · GBUniversity of California, Merced · US

Funding

Summer Research in Vascular Surgery (SRVS)T35HL155018 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Edith Tzeng · 2022 to 2026
$176k
NHLBI NIH HHS T35 HL155018
6 · The paper itself

Abstract

backgroundNonthermal endovenous closure techniques are routinely utilized to treat superficial axial venous reflux. Cyanoacrylate closure is a safe and effective modality implemented for truncal closure. However, an adverse reaction of type IV hypersensitivity (T4H), unique to cyanoacrylate, is a known risk. This study aims to evaluate the real-world incidence of T4H and examine risk factors that may predispose its development.

methodsA retrospective review between 2012- and 2022 was performed at four tertiary US institutions to examine patients who underwent cyanoacrylate vein closure of their saphenous veins. Patient demographics, comorbidities, CEAP (Clinical [C], Etiological [E], Anatomical [A], and Pathophysiological [P]) classification, and periprocedural outcomes were included. The primary endpoint was development of T4H post procedure. Logistic regression analysis for risk factors predictive of T4H was performed. Variables with a P-value of <0.05 were deemed significant.

results595 patients underwent 881 cyanoacrylate venous closures. Mean age was 66.2 ± 14.9, and 66% of patients were female. There were 92 (10.4%) T4H events in 79 (13%) patients. Oral steroids were administered to 23% for persistent and/or severe symptoms. There were no systemic allergic reactions to cyanoacrylate. Multivariate analysis revealed younger age (P = 0.015), active smoking status (P = 0.033), and CEAP 3 (P < 0.001) and 4 (P = 0.005) classifications as independent risk factors associated with development of T4H.

conclusionsThis real-world multicenter study shows the overall incidence of T4H to be 10%. CEAP 3 and 4 patients of younger age and smokers predicted a higher risk of T4H to cyanoacrylate.

Indexed as

Hypersensitivity, DelayedVaricose VeinsVenous InsufficiencyAgedAged, 80 and overCyanoacrylatesFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsSaphenous VeinTreatment OutcomeCyanoacrylates

Identifiers

PMID37301253
PMCPMC13368409
OpenAlexW4380046294

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.