Evidence map›Paper›PMID 37300819›Full record

ArticleEpigenetics2023

Sex-specific DNA methylation in saliva from the multi-ethnic Future of Families and Child Wellbeing Study.

Allison Reiner, Kelly M Bakulski, Jonah D Fisher, John F Dou, Lisa Schneper, Colter Mitchell, Daniel A Notterman, Matthew Zawistowski, Erin B Ware

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. The Impact of Early Life Adversity on Peripubertal Accelerated Epigenetic Aging and Psychopathology.Journal of the American Academy of Child and Adolescent Psychiatry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Allison ReinerDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Kelly M BakulskiDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Jonah D FisherSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
John F DouDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Lisa SchneperDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Colter MitchellSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Daniel A NottermanDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Matthew ZawistowskiDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Erin B WareSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-4731-8158
University of Michigan · USPrinceton University · US

Funding

Reciprocal Genetic-Environmental Interactions During Childhood and AdolescenceR01HD076592 · NICHD · PRINCETON UNIVERSITY · PI NOTTERMAN, DANIEL A. · 2013 to 2023
$6.8M
Epigenetic Mediation of Adverse Social Context on Stress Response, Socioemotional Development, and Health in a Population-based Study of Minority and Low SES Children and AdolescentsR01MD011716 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MITCHELL, COLTER M.S. · 2017 to 2022
$4.6M
DNA Methylation, Genetics, and Modifiable Risk Factors of Dementia in a Nationally Representative, Multi-Ethnic Cohort - Diversity SupplementR01AG067592 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, WARE, ERIN BAKSHIS · 2020 to 2025
$3.8M
Characterizing disparities in late-onset Alzheimer's disease risk through polygenic risk and epidemiologic factors in the Health and Retirement SurveyR01AG055406 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, WARE, ERIN BAKSHIS · 2017 to 2020
$1.7M
Genomics for Social Scientists: 2022-2027R25AG053227 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, COLTER M.S. MITCHELL · 2016 to 2026
$1.6M
NIA NIH HHS R01 AG055406NIA NIH HHS R01 AG067592NIA NIH HHS R25 AG053227NICHD NIH HHS R01 HD076592NIMHD NIH HHS R01 MD011716
6 · The paper itself

Abstract

The prevalence and severity of many diseases differs by sex, potentially due to sex-specific patterns in DNA methylation. Autosomal sex-specific differences in DNA methylation have been observed in cord blood and placental tissue but are not well studied in saliva or in diverse populations. We sought to characterize sex-specific DNA methylation on autosomal chromosomes in saliva samples from children in the Future of Families and Child Wellbeing Study, a multi-ethnic prospective birth cohort containing an oversampling of Black, Hispanic and low-income families. DNA methylation from saliva samples was analysed on 796 children (50.6% male) at both ages 9 and 15 with DNA methylation measured using the Illumina HumanMethylation 450k array. An epigenome-wide association analysis of the age 9 samples identified 8,430 sex-differentiated autosomal DNA methylation sites (

Indexed as

DNA MethylationEpigenesis, GeneticAdolescentChildChild HealthCpG IslandsFemaleGenome-Wide Association StudyHumansMalePlacentaPregnancyProspective StudiesSalivaAMDHD2autosomal chromosomesDNA methylationepigenetic epidemiologysalivasex differences

Identifiers

PMID37300819
PMCPMC10259311
OpenAlexW4380151097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.