SynthesisEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2023
The role of relaxin in anterior cruciate ligament injuries: a systematic review.
Synthesis in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Integrating Mechanical Loading, Mechanotransduction, and Biological Responses in Musculoskeletal Tissues Across the Lifespan: Regulation Influenced by Cells, Extracellular Matrix, and Sex.Results and problems in cell differentiation · 2026Review
- Ex vivo robotic measurement of the acute biomechanical impact of anterior cruciate ligament rupture in rats.Journal of biomechanics · 2025Article
- Return to Previous Levels of Performance Around 10 Months After Anterior Cruciate Ligament Reconstruction Using Bone-Patellar Tendon-Bone Autograft Does Not Delay Signal Intensity Reduction in a Graft: A Serial 3.0-T MRI Study.Orthopaedic journal of sports medicine · 2025Article
- Use of Handgrip Strength as a Health Indicator in Public Sector Workers: A Cross-Sectional Study.Journal of functional morphology and kinesiology · 2025Article
- Relaxin as a treatment for musculoskeletal fibrosis: What we know and future directions.Biochemical pharmacology · 2024Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAnterior cruciate ligament (ACL) tears are exceedingly common among the athletic population and are seen with higher incidence in females. Observational studies have noted peak ACL tear rates in the luteal phase of the menstrual cycle, a time in which the hormone relaxin peaks in serum concentration.
methodsA systematic review of the literature was performed. Inclusion criteria specified all prospective and retrospective studies which included the role of relaxin in the pathogenesis of ACL tears.
resultsSix studies met inclusion criteria yielding 189 subjects from clinical studies and 51 in vitro samples. Included studies found that ACL samples exhibit selective relaxin binding. When pre-treated with estrogen prior to relaxin exposure, female ACL tissue samples exhibit increased expression of collagen degrading receptors.
conclusionRelaxin displays binding specificity to the female ACL and increased serum concentrations are correlated with increased ACL tear rates in female athletes. Further research is needed in this area. LEVEL OF EVIDENCE: V.
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Registered trials
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