ArticleEpilepsia2023
Stereoelectroencephalography-guided radiofrequency ablation of the epileptogenic zone as a treatment and predictor of future success of further surgical intervention.
Article in Epilepsia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Right amygdala ablation reduces maladaptive negative interpretation bias and symptoms in a patient with post-traumatic stress disorder.Nature communications · 2026Article
- From competition to complementarity: narrative review of laser interstitial thermal therapy, focused ultrasound, and radiofrequency ablation in minimally invasive neurosurgery.Annals of medicine and surgery (2012) · 2026Review
- Robotic Surgery in Pediatric Epilepsy : Current Evidence, Clinical Impact, and Future Directions.Journal of Korean Neurosurgical Society · 2026Article
- Initial Clinical Experience with the First FDA-Approved sEEG-Guided Radiofrequency Ablation System Featuring Real-Time Temperature Monitoring: A Case Series.Stereotactic and functional neurosurgery · 2026Article
- Stereoelectroencephalography-guided radiofrequency thermocoagulation for secondary occipital lobe epilepsy in a child: a case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Association between enlarged perivascular space (ePVS) density and stereo-electroencephalography (SEEG) biomarkers of epileptogenicity.Epilepsia · 2025Article
- Cortical stimulation predicts language decline following SEEG radiofrequency thermocoagulation.Brain : a journal of neurology · 2025Observational
- Temporopolar epilepsy stereoEEG: implant technique and outcomes.Epilepsy & behavior reports · 2025Article
- Radiofrequency thermocoagulation in focal epilepsy: A retrospective cohort study.Epilepsia open · 2025Article
- SEEG in 2025: progress and pending challenges in stereotaxy methods, biomarkers and radiofrequency thermocoagulation.Current opinion in neurology · 2025Review
- Direct MRI-guided stereotactic radiofrequency thermal ablation for mesial temporal lobe epilepsy: illustrative cases.Journal of neurosurgery. Case lessons · 2025Article
- Stereoelectroencephalography-Guided Radiofrequency Thermocoagulation: Diagnostic and Therapeutic Implications.Brain sciences · 2024Review
- An exploratory computational analysis in mice brain networks of widespread epileptic seizure onset locations along with potential strategies for effective intervention and propagation control.Frontiers in computational neuroscience · 2024Article
- Epilepsy Networks and Their Surgical Relevance.Brain sciences · 2023Review
- Advanced Technology Clinic Provides Personalized Approach to Pediatric Epilepsy Surgery: Early Data and Future Directions.Missouri medicineArticle
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveStereoelectroencephalography (SEEG)-guided radiofrequency ablation (RFA) is increasingly being used as a treatment for drug-resistant localization-related epilepsy. The aim of this study is to analyze the successes and failures using RFA and how response correlates with surgical epilepsy treatment outcomes.
methodsWe retrospectively reviewed 62 patients who underwent RFA via SEEG electrodes. After excluding five, the remaining 57 were classified into subgroups based on procedures and outcomes. Forty patients (70%) underwent a secondary surgical procedure, of whom 32 were delayed: 26 laser interstitial thermal therapy (LITT), five resection, one neuromodulation. We determined the predictive value of RFA outcome upon subsequent surgical outcome by categorizing the delayed secondary surgery outcome as success (Engel I/II) versus failure (Engel III/IV). Demographic information, epilepsy characteristics, and the transient time of seizure freedom after RFA were calculated for each patient.
resultsTwelve of 49 patients (24.5%) who had RFA alone and delayed follow-up achieved Engel class I. Of the 32 patients who underwent a delayed secondary surgical procedure, 15 achieved Engel class I and nine Engel class II (24 successes), and eight were considered failures (Engel class III/IV). The transient time of seizure freedom after RFA was significantly longer in the success group (4 months, SD = 2.6) as compared to the failure group (.75 months, SD = 1.16; p < .001). Additionally, there was a higher portion of preoperative lesional findings in patients in the RFA alone and delayed surgical success group (p = .03) and a longer time to seizure recurrence in the presence of lesions (p < .05). Side effects occurred in 1% of patients. SIGNIFICANCE: In this series, RFA provided a treatment during SEEG-guided intracranial monitoring that led to seizure freedom in ~25% of patients. Of the 70% who underwent delayed surgery, longer transient time of seizure freedom after RFA was predictive of the results of the secondary surgeries, 74% of which were LITT.
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