Evidence map›Paper›PMID 37300448›Full record

ArticleAdvanced healthcare materials2023

Injectable, Antibacterial, and Hemostatic Tissue Sealant Hydrogels.

Reihaneh Haghniaz, Hossein Montazerian, Atiya Rabbani, Avijit Baidya, Brent Usui, Yangzhi Zhu, Maryam Tavafoghi, Fazli Wahid, Han-Jun Kim, Amir Sheikhi and 1 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
18.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 65 citations in OpenAlex.

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  7. Liquid Trisilanol i-Octyl POSS Achieves Rapid Hemostasis and Pneumostasis in Experimental Lung Injury.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
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  14. Sequential-Crosslinking Fibrin Glue for Rapid and Reinforced Hemostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Reihaneh HaghniazTerasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, CA, 90024, USA.
Hossein MontazerianTerasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, CA, 90024, USA.
Atiya RabbaniDepartment of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA.
Avijit BaidyaDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Brent UsuiTerasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, CA, 90024, USA.
Yangzhi ZhuTerasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, CA, 90024, USA.
Maryam TavafoghiDepartment of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA.
Fazli WahidDepartment of Biomedical Sciences, Pak-Austria Fachhochschule, Institute of Applied Sciences and Technology, Haripur, 22620, Pakistan.
Han-Jun KimTerasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, CA, 90024, USA.
Amir SheikhiDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.ORCID 0000-0002-4495-6675
Ali KhademhosseiniTerasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, CA, 90024, USA.
California NanoSystems Institute · USTerasaki Foundation · USFranklin W. Olin College of Engineering · USKorea University · KRPakistan Institute of Engineering and Applied Sciences · PKPennsylvania State University · USSRM Institute of Science and Technology · IN

Funding

Drug eluting injectable biomaterials for next generation chemoembolizationR01CA257558 · NCI · MAYO CLINIC ARIZONA · PI KHADEMHOSSEINI, ALI, OKLU, RAHMI · 2021 to 2025
$3.2M
Engineering highly elastic surgical sealants with hemostatic propertiesR01HL140618 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2018 to 2021
$2.8M
Engineering a naturally derived and highly adhesive surgical sealantR01EB023052 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2017 to 2022
$2.4M
Healing enterocutaneous fistulas using bioengineered biomaterialsR01DK130566 · NIDDK · MAYO CLINIC ARIZONA · PI KHADEMHOSSEINI, ALI, OKLU, RAHMI · 2022 to 2025
$2.2M
NCI NIH HHS R01 CA257558NHLBI NIH HHS R01 HL140618NIBIB NIH HHS R01 EB023052NIDDK NIH HHS R01 DK130566NIH HHS 1R01EB023052NIH HHS 1R01HL140618NIH HHS CA257558NIH HHS DK130566
6 · The paper itself

Abstract

Hemorrhage and bacterial infections are major hurdles in the management of life-threatening surgical wounds. Most bioadhesives for wound closure lack sufficient hemostatic and antibacterial properties. Furthermore, they suffer from weak sealing efficacy, particularly for stretchable organs, such as the lung and bladder. Accordingly, there is an unmet need for mechanically robust hemostatic sealants with simultaneous antibacterial effects. Here, an injectable, photocrosslinkable, and stretchable hydrogel sealant based on gelatin methacryloyl (GelMA), supplemented with antibacterial zinc ferrite (ZF) nanoparticles and hemostatic silicate nanoplatelets (SNs) for rapid blood coagulation is nanoengineered. The hydrogel reduces the in vitro viability of Staphylococcus aureus by more than 90%. The addition of SNs (2% w/v) and ZF nanoparticles (1.5 mg mL

Indexed as

HemostaticsHydrogelsAnimalsAnti-Bacterial AgentsHemostasisRatsSilicatesSwineAnti-Bacterial AgentsHemostaticsHydrogelsSilicatesantimicrobial hemostatsbioadhesivesbleeding woundshydrogelssealants

Identifiers

PMID37300448
PMCPMC10710521
OpenAlexW4380200292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.