ArticleMedical science monitor : international medical journal of experimental and clinical research2023
Deciphering the Influence of Estradiol and Estrogen Receptors on Cognitive Function: A Bibliometric Analysis and Emerging Research Trends.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Research advances on estrogen deficiency leading to depression.Translational neuroscience · 2026Review
- Exploiting gender-based biomarkers and drug targets: advancing personalized therapeutic strategies in hepatocellular carcinoma.Frontiers in pharmacology · 2024Review
- The impact of 17β-estradiol on the estrogen-deficient female brain: from mechanisms to therapy with hot flushes as target symptoms.Frontiers in endocrinology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND The cognitive impact of estradiol (E2), a sex steroid hormone, particularly its unique characteristics mediated through different estrogen receptors (ERs), is garnering research interest to optimize estrogen replacement therapy (ERT) and mitigate adverse effects. However, a systematic bibliometric investigation elucidating the connection between E2/ERs and cognition is lacking. This study examines 3502 Web of Science Core Collection publications using CiteSpace to unveil trends in this research field. MATERIAL AND METHODS The primary goal was to analyze highly co-cited articles characterized by extensive citation, centrality, Sigma index, and burst strength. We identified six research themes and directions from ten distinct, highly credible clusters (Q=0.8266; S=0.978), established by frequently employed keywords. Secondly, we sought to highlight the most contributing countries, institutions, and authors in this domain. RESULTS The study unveiled that the 'critical age window period' hypothesis of ERT, hippocampus-derived E2, the mediating role of GPER, and crosstalk among ERs are the current hotspots in this field. Future research is likely to explore the links between E2/ERs and the hippocampus, various memory types, sex specificity, and receptor specificity. The United States and the University of Wisconsin have the most publications, while Scotland and Stanford University have the highest centrality. The most influential authors are Woolley CS, Frick KM, Tuscher JJ, and Espeland MA. CONCLUSIONS These findings inform prospective research directions and hint at potential E2 targets for cognitive enhancement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.