Evidence map›Paper›PMID 37299315›Full record

ReviewPolymers2023

How to Develop Drug Delivery System Based on Carbohydrate Nanoparticles Targeted to Brain Tumors.

Vladimir E Silant'ev, Mikhail E Shmelev, Andrei S Belousov, Aleksandra A Patlay, Roman A Shatilov, Vladislav M Farniev, Vadim V Kumeiko

Open access · goldAbstract readReview
In one paragraph

Review in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Formulation andCurrent pharmaceutical design · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Review of Antimicrobial Properties of Titanium Dioxide Nanoparticles.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Vladimir E Silant'evInstitute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.ORCID 0000-0003-1202-4176
Mikhail E ShmelevInstitute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.
Andrei S BelousovInstitute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.ORCID 0000-0001-8257-3109
Aleksandra A PatlayInstitute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.
Roman A ShatilovInstitute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.
Vladislav M FarnievInstitute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.
Vadim V KumeikoInstitute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.ORCID 0000-0002-1639-664X
Far Eastern Federal University · RU

Funding

Russian Science Foundation 22-73-10172
6 · The paper itself

Abstract

Brain tumors are the most difficult to treat, not only because of the variety of their forms and the small number of effective chemotherapeutic agents capable of suppressing tumor cells, but also limited by poor drug transport across the blood-brain barrier (BBB). Nanoparticles are promising drug delivery solutions promoted by the expansion of nanotechnology, emerging in the creation and practical use of materials in the range from 1 to 500 nm. Carbohydrate-based nanoparticles is a unique platform for active molecular transport and targeted drug delivery, providing biocompatibility, biodegradability, and a reduction in toxic side effects. However, the design and fabrication of biopolymer colloidal nanomaterials have been and remain highly challenging to date. Our review is devoted to the description of carbohydrate nanoparticle synthesis and modification, with a brief overview of the biological and promising clinical outcomes. We also expect this manuscript to highlight the great potential of carbohydrate nanocarriers for drug delivery and targeted treatment of gliomas of various grades and glioblastomas, as the most aggressive of brain tumors.

Indexed as

blood–brain barrierdrug deliveryglioblastomananoparticlesnatural polymerspolysaccharides

Identifiers

PMID37299315
PMCPMC10255125
OpenAlexW4378907927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.