ArticlePolymers2023
A Red-Light-Responsive DASA-Polymer with High Water Stability for Controlled Release.
Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From Visible to Near-Infrared Light-Triggered Photochromism: Negative Photochromism.Molecules (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Photoresponsive polymers hold vast potential in the realm of drug delivery. Currently, most photoresponsive polymers use ultraviolet (UV) light as the excitation source. However, the limited penetration ability of UV light within biological tissues serves as a significant hindrance to their practical applications. Given the strong penetration ability of red light in biological tissues, the design and preparation of a novel red-light-responsive polymer with high water stability, incorporating the reversible photoswitching compound and donor-acceptor Stenhouse adducts (DASA) for controlled drug release is demonstrated. In aqueous solutions, this polymer exhibits self-assembly into micellar nanovectors (~33 nm hydrodynamic diameter), facilitating the encapsulation of the hydrophobic model drug Nile red (NR) within the micellar core. Upon irradiation by a 660 nm LED light source, photons are absorbed by DASA, leading to the disruption of the hydrophilic-hydrophobic balance of the nanovector and thereby resulting in the release of NR. This newly designed nanovector incorporates red light as a responsive switch, successfully avoiding the problems of photodamage and limited penetration of UV light within biological tissues, thereby further promoting the practical applications of photoresponsive polymer nanomedicines.
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Registered trials
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