Evidence map›Paper›PMID 37299207›Full record

ArticlePlants (Basel, Switzerland)2023

Plant-Produced Nanoparticles Based on Artificial Self-Assembling Peptide Bearing the Influenza M2e Epitope.

Elena A Blokhina, Eugenia S Mardanova, Anna A Zykova, Liudmila A Stepanova, Marina A Shuklina, Liudmila M Tsybalova, Nikolai V Ravin

Open access · goldAbstract read
In one paragraph

Article in Plants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Elena A BlokhinaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.
Eugenia S MardanovaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0003-2148-7658
Anna A ZykovaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0001-9577-4815
Liudmila A StepanovaSmorodintsev Research Institute of Influenza, Russian Ministry of Health, 197376 St. Petersburg, Russia.ORCID 0000-0002-8731-1834
Marina A ShuklinaSmorodintsev Research Institute of Influenza, Russian Ministry of Health, 197376 St. Petersburg, Russia.
Liudmila M TsybalovaSmorodintsev Research Institute of Influenza, Russian Ministry of Health, 197376 St. Petersburg, Russia.ORCID 0000-0002-1193-5907
Nikolai V RavinInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0002-1456-1832
Russian Academy of Sciences · RUMinistry of Health of the Russian Federation · RU

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2022-318
6 · The paper itself

Abstract

Despite advances in vaccine development, influenza remains a persistent global health threat and the search for a broad-spectrum recombinant vaccine against influenza continues. The extracellular domain of the transmembrane protein M2 (M2e) of the influenza A virus is highly conserved and can be used to develop a universal vaccine. M2e is a poor immunogen by itself, but it becomes highly immunogenic when linked to an appropriate carrier. Here, we report the transient expression of a recombinant protein comprising four tandem copies of M2e fused to an artificial self-assembling peptide (SAP) in plants. The hybrid protein was efficiently expressed in

Indexed as

influenza AM2e peptidenanoparticleNicotiana benthamianaplantself-assembling peptidetransient expressionvaccineviral vector

Identifiers

PMID37299207
PMCPMC10255905
OpenAlexW4379518955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.