Evidence map›Paper›PMID 37298988›Full record

ArticleMolecules (Basel, Switzerland)2023

Piplartine-Inspired 3,4,5-Trimethoxycinnamates: Trypanocidal, Mechanism of Action, and In Silico Evaluation.

Carlos S M B Filho, Ramon R P P B de Menezes, Emanuel P Magalhães, Yunierkis P Castillo, Alice M C Martins, Damião P de Sousa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carlos S M B FilhoDepartment of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.ORCID 0000-0003-0628-5783
Ramon R P P B de MenezesDepartment of Clinical and Toxicological Analysis, Federal University of Ceará, Fortaleza 60020-181, CE, Brazil.ORCID 0000-0003-3109-9683
Emanuel P MagalhãesDepartment of Clinical and Toxicological Analysis, Federal University of Ceará, Fortaleza 60020-181, CE, Brazil.
Yunierkis P CastilloEscuela de Ciencias Físicas y Matemáticas, Universidad de Las Américas, Quito 170125, Ecuador.ORCID 0000-0002-3710-0035
Alice M C MartinsDepartment of Clinical and Toxicological Analysis, Federal University of Ceará, Fortaleza 60020-181, CE, Brazil.
Damião P de SousaDepartment of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.ORCID 0000-0002-7180-4896

Funding

Fundação de Apoio à Pesquisa do Estado da Paraíba PIG14859-2021
6 · The paper itself

Abstract

Chagas disease (CD) is one of the main neglected tropical diseases that promote relevant socioeconomic impacts in several countries. The therapeutic options for the treatment of CD are limited, and parasite resistance has been reported. Piplartine is a phenylpropanoid imide that has diverse biological activities, including trypanocidal action. Thus, the objective of the present work was to prepare a collection of thirteen esters analogous to piplartine (

Indexed as

Chagas DiseaseTrypanocidal AgentsTrypanosoma cruziHumansMolecular Docking SimulationOxidative StressTrypanocidal Agentsalkamideantiparasitic activitymolecular dockingnatural productsneglected diseasesphenylpropanoidpiperlonguminepiplartineTrypanosoma cruzi

Identifiers

PMID37298988
PMCPMC10254306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.