Evidence map›Paper›PMID 37298873›Full record

ArticleMolecules (Basel, Switzerland)2023

Light-Elicited and Oxygen-Saved Iridium Nanocapsule for Oxidative Damage Intensified Oncotherapy.

Guobo Chen, Xiang Wang, Zongyan He, Xueyu Li, Zhijin Yang, Yule Zhang, Yuhao Li, Lulu Zheng, Yuqing Miao, Dawei Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Guobo ChenSchool of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China.
Xiang WangSchool of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China.
Zongyan HeSchool of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China.
Xueyu LiSchool of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China.
Zhijin YangShanghai Environmental Biosafety Instruments and Equipment Engineering Technology Research Center, Engineering Research Center of Optical Instrument and System, The Ministry of Education & Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, China.
Yule ZhangShanghai Environmental Biosafety Instruments and Equipment Engineering Technology Research Center, Engineering Research Center of Optical Instrument and System, The Ministry of Education & Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, China.
Yuhao LiSchool of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China.ORCID 0000-0001-7146-8645
Lulu ZhengShanghai Environmental Biosafety Instruments and Equipment Engineering Technology Research Center, Engineering Research Center of Optical Instrument and System, The Ministry of Education & Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, China.
Yuqing MiaoSchool of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China.
Dawei ZhangShanghai Environmental Biosafety Instruments and Equipment Engineering Technology Research Center, Engineering Research Center of Optical Instrument and System, The Ministry of Education & Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, China.
University of Shanghai for Science and Technology · CN

Funding

Ministry of Science and Technology of China 2021YFE0111300National Key Research and Development Program of China 2020YFA0909000National Natural Science Foundation of China 82127807Natural Science Foundation of Shanghai 19ZR1434700Shanghai Key Laboratory of Molecular Imaging 18DZ2260400
6 · The paper itself

Abstract

Regulating redox homeostasis in tumor cells and exploiting oxidative stress to damage tumors is an efficacious strategy for cancer therapy. However, the strengths of organic nanomaterials within this strategy are often ignored. In this work, a light-triggered reactive oxygen species (ROS) damaging nanoamplifier (IrP-T) was developed for enhanced photodynamic therapy (PDT). The IrP-T was fabricated with an amphiphilic iridium complex and a MTH1 inhibitor (TH287). Under green light stimulation, IrP-T catalyzed the oxygen in cells to generate ROS for realizing oxidative damage; meanwhile, TH287 increased the accumulation of 8-oxo-dGTP, further strengthening oxidative stress and inducing cell death. IrP-T could maximize the use of a small amount of oxygen, thus further boosting the efficacy of PDT in hypoxic tumors. The construction of nanocapsules provided a valuable therapeutic strategy for oxidative damage and synergizing PDT.

Indexed as

NanocapsulesNeoplasmsPhotochemotherapyCell Line, TumorHumansIridiumOxidative StressOxygenPhotosensitizing AgentsReactive Oxygen SpeciesIridiumNanocapsulesOxygenPhotosensitizing AgentsReactive Oxygen Speciesenhanced photodynamic therapyiridium complexoxidative damageself-assemblyTH287

Identifiers

PMID37298873
PMCPMC10254276
OpenAlexW4378619321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.