Evidence map›Paper›PMID 37298811›Full record

ArticleMolecules (Basel, Switzerland)2023

Early Molecular Insights into Thanatin Analogues Binding to

Kathryn K Oi, Kerstin Moehle, Matthias Schuster, Oliver Zerbe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kathryn K OiDepartment of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Kerstin MoehleDepartment of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Matthias SchusterDepartment of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.ORCID 0000-0002-3008-3957
Oliver ZerbeDepartment of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.ORCID 0000-0003-0475-438X
University of Zurich · CH

Funding

Innosuisse - Swiss Innovation Agency 33285.1 IP-LS
6 · The paper itself

Abstract

The cationic antimicrobial ß-hairpin, thanatin, was recently developed into drug-like analogues active against carbapenem-resistant Enterobacteriaceae (CRE). The analogues represent new antibiotics with a novel mode of action targeting LptA in the periplasm and disrupting LPS transport. The compounds lose antimicrobial efficacy when the sequence identity to

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBacterial ProteinsCarrier ProteinsAmino Acid SequenceConserved SequenceProtein BindingProtein ConformationAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBacterial ProteinsCarrier ProteinsthanatinA. baumanniiantimicrobial resistancebinding constantsGram-negative bacteriaLPS transportLptANMR structurethanatinthanatin analogues

Identifiers

PMID37298811
PMCPMC10254193
OpenAlexW4378472409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.