Evidence map›Paper›PMID 37298697›Full record

ArticleInternational journal of molecular sciences2023

Resveratrol Reverses Endothelial Colony-Forming Cell Dysfunction in Adulthood in a Rat Model of Intrauterine Growth Restriction.

Estelle Guillot, Anna Lemay, Manon Allouche, Sara Vitorino Silva, Hanna Coppola, Florence Sabatier, Françoise Dignat-George, Alexandre Sarre, Anne-Christine Peyter, Stéphanie Simoncini and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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  6. Targeting L-arginine/NO/cGMP/KFrontiers in pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Estelle GuillotDOHaD Laboratory, Division of pediatrics, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Anna LemayDOHaD Laboratory, Division of pediatrics, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Manon AlloucheDOHaD Laboratory, Division of pediatrics, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Sara Vitorino SilvaDOHaD Laboratory, Division of pediatrics, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Hanna CoppolaDOHaD Laboratory, Division of pediatrics, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Florence SabatierCenter from Cardiovascular and Nutrition Research (C2VN), Institut National de la Santé Et de la Recherche Médicale (INSERM), Aix Marseille Université, UMR-S 1263, UFR de Pharmacie, Campus Santé, 13385 Marseille, France.
Françoise Dignat-GeorgeCenter from Cardiovascular and Nutrition Research (C2VN), Institut National de la Santé Et de la Recherche Médicale (INSERM), Aix Marseille Université, UMR-S 1263, UFR de Pharmacie, Campus Santé, 13385 Marseille, France.
Alexandre SarreDOHaD Laboratory, Division of pediatrics, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Anne-Christine PeyterNeonatal Research Laboratory, Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0003-2051-1126
Stéphanie SimonciniCenter from Cardiovascular and Nutrition Research (C2VN), Institut National de la Santé Et de la Recherche Médicale (INSERM), Aix Marseille Université, UMR-S 1263, UFR de Pharmacie, Campus Santé, 13385 Marseille, France.ORCID 0000-0002-8062-5005
Catherine YzydorczykDOHaD Laboratory, Division of pediatrics, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0002-0617-7558
University of Lausanne · CHInserm · FR

Funding

AIRG Switzerland 10172
6 · The paper itself

Abstract

Individuals born after intrauterine growth restriction (IUGR) are at risk of developing cardiovascular diseases (CVDs). Endothelial dysfunction plays a role in the pathogenesis of CVDs; and endothelial colony-forming cells (ECFCs) have been identified as key factors in endothelial repair. In a rat model of IUGR induced by a maternal low-protein diet, we observed an altered functionality of ECFCs in 6-month-old males, which was associated with arterial hypertension related to oxidative stress and stress-induced premature senescence (SIPS). Resveratrol (R), a polyphenol compound, was found to improve cardiovascular function. In this study, we investigated whether resveratrol could reverse ECFC dysfunctions in the IUGR group. ECFCs were isolated from IUGR and control (CTRL) males and were treated with R (1 μM) or dimethylsulfoxide (DMSO) for 48 h. In the IUGR-ECFCs, R increased proliferation (5'-bromo-2'-deoxyuridine (BrdU) incorporation,

Indexed as

Cardiovascular DiseasesFetal Growth RetardationAnimalsCell ProliferationCells, CulturedEndothelial CellsFemaleFluorescent DyesHumansMaleRatsResveratrolFluorescent DyesResveratroldevelopmental programmingendothelial colony-forming cellsintrauterine growth restrictionoxidative stressresveratrolstress-induced premature senescence

Identifiers

PMID37298697
PMCPMC10253508
OpenAlexW4379469607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.