Evidence map›Paper›PMID 37298678›Full record

SynthesisInternational journal of molecular sciences2023

Current State of Knowledge Regarding WHO High Priority Pathogens-Resistance Mechanisms and Proposed Solutions through Candidates Such as Essential Oils: A Systematic Review.

Mirabela Romanescu, Camelia Oprean, Adelina Lombrea, Bianca Badescu, Ana Teodor, George D Constantin, Minodora Andor, Roxana Folescu, Delia Muntean, Corina Danciu and 4 more

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Polymyxin-resistant hypervirulentFrontiers in microbiology · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Green Synthesized Polymeric Iodophors with Thyme as Antimicrobial Agents.International journal of molecular sciences · 2024
    Article
  18. Frontiers in chemistry · 2024
    Article
  19. Evidence of potentialMicrobial genomics · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Mirabela RomanescuDoctoral School, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.ORCID 0000-0002-7848-1786
Camelia OpreanFaculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.
Adelina LombreaDoctoral School, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.ORCID 0000-0002-6576-965X
Bianca BadescuDoctoral School, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.
Ana TeodorDoctoral School, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.
George D ConstantinDoctoral School, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.
Minodora AndorFaculty of Medicine, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.
Roxana FolescuFaculty of Medicine, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.
Delia MunteanFaculty of Medicine, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.ORCID 0000-0001-9100-4530
Corina DanciuFaculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.ORCID 0000-0001-5999-1214
Olivia DalleurLouvain Drug Research Institute, Université Catholique de Louvain, Avenue Emmanuel Mounier 73, 1200 Brussels, Belgium.
Stefan Laurentiu BatrinaFaculty of Agriculture, University of Life Sciences "King Mihai I" from Timisoara, Calea Aradului 119, 300645 Timisoara, Romania.ORCID 0000-0001-5622-8838
Octavian CretuFaculty of Medicine, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.
Valentina Oana BudaFaculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.ORCID 0000-0002-3194-2012
Victor Babeș University of Medicine and Pharmacy Timișoara · ROSpitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" Timişoara · ROUCLouvain · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combating antimicrobial resistance (AMR) is among the 10 global health issues identified by the World Health Organization (WHO) in 2021. While AMR is a naturally occurring process, the inappropriate use of antibiotics in different settings and legislative gaps has led to its rapid progression. As a result, AMR has grown into a serious global menace that impacts not only humans but also animals and, ultimately, the entire environment. Thus, effective prophylactic measures, as well as more potent and non-toxic antimicrobial agents, are pressingly needed. The antimicrobial activity of essential oils (EOs) is supported by consistent research in the field. Although EOs have been used for centuries, they are newcomers when it comes to managing infections in clinical settings; it is mainly because methodological settings are largely non-overlapping and there are insufficient data regarding EOs' in vivo activity and toxicity. This review considers the concept of AMR and its main determinants, the modality by which the issue has been globally addressed and the potential of EOs as alternative or auxiliary therapy. The focus is shifted towards the pathogenesis, mechanism of resistance and activity of several EOs against the six high priority pathogens listed by WHO in 2017, for which new therapeutic solutions are pressingly required.

Indexed as

Anti-Infective AgentsOils, VolatileAnimalsAnti-Bacterial AgentsDrug Resistance, BacterialHumansWorld Health OrganizationAnti-Bacterial AgentsAnti-Infective AgentsOils, Volatilecephalosporin-resistantclarithromycin-resistant Helicobacter pylorifluoroquinolone-resistant Campylobacter spp.fluoroquinolone-resistant Neisseria gonorrhoeaefluoroquinolone-resistant Salmonellaemethicillin-resistantmultidrug-resistant strainsnosocomial infectionsvancomycin-resistant Enterococcus faeciumvancomycin-resistant Staphylococcus aureus

Identifiers

PMID37298678
PMCPMC10253476
OpenAlexW4379472633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.