Evidence map›Paper›PMID 37298676›Full record

ArticleInternational journal of molecular sciences2023

Synthesis of Flavonol-Bearing Probes for Chemoproteomic and Bioinformatic Analyses of Asteraceae Petals in Search of Novel Flavonoid Enzymes.

Karl Kempf, Oxana Kempf, Yoan Capello, Christian Molitor, Claire Lescoat, Rana Melhem, Stéphane Chaignepain, Elisabeth Génot, Alexis Groppi, Macha Nikolski and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Karl KempfISM (CNRS-UMR 5255), University of Bordeaux, 33405 Talence CEDEX, France.
Oxana KempfISM (CNRS-UMR 5255), University of Bordeaux, 33405 Talence CEDEX, France.
Yoan CapelloISM (CNRS-UMR 5255), University of Bordeaux, 33405 Talence CEDEX, France.
Christian MolitorInstitute of Chemical, Environmental & Bioscience Engineering, Technische Universität Wien, 1060 Vienna, Austria.ORCID 0000-0003-1685-0141
Claire LescoatCentre de Bioinformatique de Bordeaux (CBiB), University of Bordeaux, 33076 Bordeaux CEDEX, France.
Rana MelhemCentre de Recherche Cardio-Thoracique de Bordeaux (INSERM U1045), University of Bordeaux, 33607 Pessac CEDEX, France.
Stéphane ChaignepainCBMN (CNRS-UMR 5248), Centre de Génomique Fonctionnelle de Bordeaux, University of Bordeaux, 33076 Bordeaux CEDEX, France.
Elisabeth GénotCentre de Recherche Cardio-Thoracique de Bordeaux (INSERM U1045), University of Bordeaux, 33607 Pessac CEDEX, France.
Alexis GroppiCentre de Bioinformatique de Bordeaux (CBiB), University of Bordeaux, 33076 Bordeaux CEDEX, France.ORCID 0000-0002-3341-8281
Macha NikolskiCentre de Bioinformatique de Bordeaux (CBiB), University of Bordeaux, 33076 Bordeaux CEDEX, France.ORCID 0000-0001-6059-577X
Heidi HalbwirthInstitute of Chemical, Environmental & Bioscience Engineering, Technische Universität Wien, 1060 Vienna, Austria.
Denis DeffieuxISM (CNRS-UMR 5255), University of Bordeaux, 33405 Talence CEDEX, France.
Stéphane QuideauISM (CNRS-UMR 5255), University of Bordeaux, 33405 Talence CEDEX, France.ORCID 0000-0002-7079-9757
Centre National de la Recherche Scientifique · FRUniversité de Bordeaux · FRTU Wien · AT

Funding

Agence Nationale de la Recherche ANR-16-CE91-0006-01 PRCI HIGHERFLAVOAgence Nationale de la Recherche ANR-17-CE11-0033-01 PRC POLYPHENOLPROTFWF Austrian Science Fund FWF I_2919-B25
6 · The paper itself

Abstract

This study aimed at searching for the enzymes that are responsible for the higher hydroxylation of flavonols serving as UV-honey guides for pollinating insects on the petals of Asteraceae flowers. To achieve this aim, an affinity-based chemical proteomic approach was developed by relying on the use of quercetin-bearing biotinylated probes, which were thus designed and synthesized to selectively and covalently capture relevant flavonoid enzymes. Proteomic and bioinformatic analyses of proteins captured from petal microsomes of two Asteraceae species (

Indexed as

AsteraceaeFlavonoidsFlavonolsMixed Function OxygenasesPlant ProteinsProteomicsFlavonoidsFlavonolsMixed Function OxygenasesPlant ProteinsAsteraceae UV-honey guidesbioinformaticschemoproteomicsflavonoid biosynthesishigher hydroxylated flavonolsplant polyphenols

Identifiers

PMID37298676
PMCPMC10253404
OpenAlexW4379471046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.