Evidence map›Paper›PMID 37298644›Full record

ReviewInternational journal of molecular sciences2023

Cannabidiol for Oral Health: A New Promising Therapeutical Tool in Dentistry.

Luigi Bellocchio, Assunta Patano, Alessio Danilo Inchingolo, Francesco Inchingolo, Gianna Dipalma, Ciro Gargiulo Isacco, Elisabetta de Ruvo, Biagio Rapone, Antonio Mancini, Felice Lorusso and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Luigi BellocchioINSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, University of Bordeaux, 33063 Bordeaux, France.
Assunta PatanoDepartment of Interdisciplinary Medicine, University of Study "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-7395-3126
Alessio Danilo InchingoloDepartment of Interdisciplinary Medicine, University of Study "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-6366-1039
Francesco InchingoloDepartment of Interdisciplinary Medicine, University of Study "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-3797-5883
Gianna DipalmaDepartment of Interdisciplinary Medicine, University of Study "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-5947-8987
Ciro Gargiulo IsaccoDepartment of Interdisciplinary Medicine, University of Study "Aldo Moro", 70124 Bari, Italy.
Elisabetta de RuvoDepartment of Interdisciplinary Medicine, University of Study "Aldo Moro", 70124 Bari, Italy.
Biagio RaponeDepartment of Interdisciplinary Medicine, University of Study "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-0062-6594
Antonio ManciniDepartment of Interdisciplinary Medicine, University of Study "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-7103-4086
Felice LorussoDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-2660-9231
Antonio ScaranoDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-1374-6146
Giuseppina MalcangiDepartment of Interdisciplinary Medicine, University of Study "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-9745-7506
Angelo Michele InchingoloDepartment of Interdisciplinary Medicine, University of Study "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-0104-6337
University of Bari Aldo Moro · ITUniversity of Chieti-Pescara · ITUniversité de Bordeaux · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The medical use of cannabis has a very long history. Although many substances called cannabinoids are present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD) and cannabinol (CBN) are the three main cannabinoids that are most present and described. CBD itself is not responsible for the psychotropic effects of cannabis, since it does not produce the typical behavioral effects associated with the consumption of this drug. CBD has recently gained growing attention in modern society and seems to be increasingly explored in dentistry. Several subjective findings suggest some therapeutic effects of CBD that are strongly supported by research evidence. However, there is a plethora of data regarding CBD's mechanism of action and therapeutic potential, which are in many cases contradictory. We will first provide an overview of the scientific evidence on the molecular mechanism of CBD's action. Furthermore, we will map the recent developments regarding the possible oral benefits of CBD. In summary, we will highlight CBD's promising biological features for its application in dentistry, despite exiting patents that suggest the current compositions for oral care as the main interest of the industry.

Indexed as

CannabidiolCannabinoidsCannabisHallucinogensCannabinolDentistryDronabinolOral HealthCannabidiolCannabinoidsCannabinolDronabinolHallucinogenscannabinoidsCBDdental medicinepatentspharmacologyplants

Identifiers

PMID37298644
PMCPMC10253521
OpenAlexW4379231200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.