Evidence map›Paper›PMID 37298606›Full record

ArticleInternational journal of molecular sciences2023

Diagnostic Utility of TSSC3 and RB1 Immunohistochemistry in Hydatidiform Mole.

Wai Kit Chia, Pik Yuen Chia, Nor Haslinda Abdul Aziz, Salwati Shuib, Muaatamarulain Mustangin, Yoke Kqueen Cheah, Teck Yee Khong, Yin Ping Wong, Geok Chin Tan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Wai Kit ChiaDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, Malaysia.
Pik Yuen ChiaDepartment of Pathology, Hospital Umum Sarawak, Kuching 93586, Sarawak, Malaysia.
Nor Haslinda Abdul AzizDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, Malaysia.
Salwati ShuibDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, Malaysia.
Muaatamarulain MustanginDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, Malaysia.ORCID 0000-0003-3834-7520
Yoke Kqueen CheahDepartment of Biomedical Science, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.ORCID 0000-0001-9258-3749
Teck Yee KhongDepartment of Pathology, Women's and Children's Hospital, Adelaide, SA 5006, Australia.ORCID 0000-0002-2404-007X
Yin Ping WongDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, Malaysia.ORCID 0000-0003-4897-9927
Geok Chin TanDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, Malaysia.ORCID 0000-0002-2289-7619
National University of Malaysia · MYSarawak General Hospital · MYUniversiti Putra Malaysia · MYWomen's and Children's Hospital · AU

Funding

Fundamental Research Grant Scheme FRGS/1/2019/SKK13/UKM/02/1
6 · The paper itself

Abstract

The general notion of complete hydatidiform moles is that most of them consist entirely of paternal DNA; hence, they do not express p57, a paternally imprinted gene. This forms the basis for the diagnosis of hydatidiform moles. There are about 38 paternally imprinted genes. The aim of this study is to determine whether other paternally imprinted genes could also assist in the diagnostic approach of hydatidiform moles. This study comprised of 29 complete moles, 15 partial moles and 17 non-molar abortuses. Immunohistochemical study using the antibodies of paternal-imprinted (RB1, TSSC3 and DOG1) and maternal-imprinted (DNMT1 and GATA3) genes were performed. The antibodies' immunoreactivity was evaluated on various placental cell types, namely cytotrophoblasts, syncytiotrophoblasts, villous stromal cells, extravillous intermediate trophoblasts and decidual cells. TSSC3 and RB1 expression were observed in all cases of partial moles and non-molar abortuses. In contrast, their expression in complete moles was identified in 31% (TSSC3) and 10.3% (RB1), respectively (

Indexed as

Hydatidiform MoleMolesAnimalsAntibodiesCyclin-Dependent Kinase Inhibitor p57FemaleHumansImmunohistochemistryNuclear ProteinsPlacentaPregnancyRetinoblastoma Binding ProteinsUbiquitin-Protein LigasesAntibodiesCyclin-Dependent Kinase Inhibitor p57Nuclear ProteinsRB1 protein, humanRetinoblastoma Binding ProteinsTSSC3 proteinUbiquitin-Protein Ligaseshydatidiform molesmolar pregnancypaternal imprinted genesRB1TSSC3

Identifiers

PMID37298606
PMCPMC10253801
OpenAlexW4379144736

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.