Evidence map›Paper›PMID 37298565›Full record

ArticleInternational journal of molecular sciences2023

Smooth Muscle-Alpha Actin R149C Pathogenic Variant Downregulates Integrin Recruitment at Cell-Matrix Adhesions and Decreases Cellular Contractility.

Krishna R Ojha, Hyoseon Kim, Samuel Padgham, Laura Hopkins, Robert J Zamen, Abhijnan Chattopadhyay, Gang Han, Dianna M Milewicz, Michael P Massett, Andreea Trache

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Integrin Signaling Pathways in Aortic Aneurysm and Dissection.Reviews in cardiovascular medicine · 2026
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Krishna R OjhaDepartment of Medical Physiology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Hyoseon KimDepartment of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0001-8933-6042
Samuel PadghamDepartment of Medical Physiology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Laura HopkinsDepartment of Epidemiology and Statistics, Texas A&M University Health Science Center, College Station, TX 77843, USA.
Robert J ZamenDepartment of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.
Abhijnan ChattopadhyayDepartment of Internal Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030, USA.ORCID 0000-0002-9907-213X
Gang HanDepartment of Epidemiology and Statistics, Texas A&M University Health Science Center, College Station, TX 77843, USA.
Dianna M MilewiczDepartment of Internal Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030, USA.
Michael P MassettDepartment of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0001-5356-4959
Andreea TracheDepartment of Medical Physiology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.ORCID 0000-0002-2070-4895
Texas A&M Health Science Center · USTexas Tech University · USThe University of Texas Health Science Center at Houston · USTexas A&M University · US

Funding

Novel genetic Insight into the molecular pathogenesis of atherosclerosisR01HL146583 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILEWICZ, DIANNA M · 2019 to 2022
$2.6M
American Heart Association 18TPA34230049NHLBI NIH HHS R01 HL146583
6 · The paper itself

Abstract

Thoracic aortic aneurysm is found in patients with

Indexed as

ActinsAortic Aneurysm, ThoracicAnimalsCell-Matrix JunctionsIntegrinsMiceMuscle, SmoothMyocytes, Smooth MuscleActinsIntegrinsActa2R149C/+ miceactinintegrinsvascular smooth muscle cells

Identifiers

PMID37298565
PMCPMC10253315
OpenAlexW4379055866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.