Evidence map›Paper›PMID 37298526›Full record

ArticleInternational journal of molecular sciences2023

Modulation of the Endomembrane System by the Anticancer Natural Product Superstolide/ZJ-101.

Phillip R Sanchez, Sarah A Head, Shan Qian, Haibo Qiu, Avishek Roy, Zhendong Jin, Wei Zheng, Jun O Liu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Phillip R SanchezNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD 20892, USA.
Sarah A HeadDepartment of Pharmacology & Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-8942-7785
Shan QianDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.
Haibo QiuDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.ORCID 0009-0000-3283-8359
Avishek RoyDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.
Zhendong JinDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.
Wei ZhengNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD 20892, USA.ORCID 0000-0003-1034-0757
Jun O LiuDepartment of Pharmacology & Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
University of Iowa · USJohns Hopkins University · USNational Institutes of Health · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Drug Repurposing Screening for Rare and Neglected DiseasesZIATR000018 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI ZHENG, WEI · 2015 to 2025
$24.6M
PHARMACOLOGY TRAINING GRANTT32GM008763 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI FREEL MEYERS, CAREN L. · 2000 to 2019
$6.1M
Chemical biology of superstolides--a novel class of anticancer natural productsR21CA204836 · NCI · UNIVERSITY OF IOWA · PI JIN, ZHENDONG, LIU, JUN O. · 2016 to 2017
$373k
NCI NIH HHS P30 CA086862NCI NIH HHS R21 CA204836NIGMS NIH HHS T32 GM008763NIH HHS 1R21CA204836-01NIH HHS 5T32GM008763
6 · The paper itself

Abstract

Marine natural products represent a unique source for clinically relevant drugs due to their vast molecular and mechanistic diversity. ZJ-101 is a structurally simplified analog of the marine natural product superstolide A, isolated from the New Caledonian sea sponge

Indexed as

Biological ProductsCell LineMacrolidesTetrahydronaphthalenesBiological ProductsMacrolidesTetrahydronaphthalenesZJ-1013D spheroidglycomicsnatural productphenotypic analysissuperstolidetranscriptomics

Identifiers

PMID37298526
PMCPMC10253484
OpenAlexW4379053842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.