Evidence map›Paper›PMID 37298523›Full record

ArticleInternational journal of molecular sciences2023

miRNA-132/212 Deficiency Disrupts Selective Corticosterone Modulation of Dorsal vs. Ventral Hippocampal Metaplasticity.

Shima Kouhnavardi, Maureen Cabatic, M Carmen Mañas-Padilla, Marife-Astrid Malabanan, Tarik Smani, Ana Cicvaric, Edison Alejandro Muñoz Aranzalez, Xaver Koenig, Ernst Urban, Gert Lubec and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. MicroRNAs as biomarkers and molecular mediators of cognitive dysfunction in schizophrenia.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Shima KouhnavardiCenter for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Maureen CabaticCenter for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria.
M Carmen Mañas-PadillaInstituto de Investigación Biomédica de Málaga-IBIMA, 29590 Málaga, Spain.
Marife-Astrid MalabananCenter for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Tarik SmaniDepartment of Medical Physiology and Biophysics, University of Seville, 41013 Seville, Spain.ORCID 0000-0002-1877-7438
Ana CicvaricCenter for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-3560-4491
Edison Alejandro Muñoz AranzalezCenter for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Xaver KoenigCenter for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-2423-4966
Ernst UrbanDepartment for Pharmaceutical Sciences, Josef-Holaubek-Platz 2, 2D 303, 1090 Vienna, Austria.
Gert LubecProgramme for Proteomics, Paracelsus Medical University, 5020 Salzburg, Austria.ORCID 0000-0002-6333-9461
Estela Castilla-OrtegaInstituto de Investigación Biomédica de Málaga-IBIMA, 29590 Málaga, Spain.ORCID 0000-0002-4496-1167
Francisco J MonjeCenter for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-6496-0030
Medical University of Vienna · ATInstituto de Investigación Biomédica de Málaga · ESAlbert Einstein College of Medicine · USParacelsus Medical University · ATUniversidad de Sevilla · ES

Funding

Austrian Science Fund FWF P 31004
6 · The paper itself

Abstract

Cortisol is a potent human steroid hormone that plays key roles in the central nervous system, influencing processes such as brain neuronal synaptic plasticity and regulating the expression of emotional and behavioral responses. The relevance of cortisol stands out in the disease, as its dysregulation is associated with debilitating conditions such as Alzheimer's Disease, chronic stress, anxiety and depression. Among other brain regions, cortisol importantly influences the function of the hippocampus, a structure central for memory and emotional information processing. The mechanisms fine-tuning the different synaptic responses of the hippocampus to steroid hormone signaling remain, however, poorly understood. Using ex vivo electrophysiology and wild type (WT) and miR-132/miR-212 microRNAs knockout (miRNA-132/212

Indexed as

CorticosteroneMicroRNAsAnimalsHippocampusHumansHydrocortisoneMiceNeuronal PlasticityCorticosteroneHydrocortisoneMicroRNAsMIRN132 microRNA, humanMIRN132 microRNA, mouseMIRN212 microRNA, humananxiety-like behaviorcorticosteronedorsal hippocampusemotional behaviormicroRNAmiR-132/212synaptic plasticityventral hippocampus

Identifiers

PMID37298523
PMCPMC10253409
OpenAlexW4379058107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.