Evidence map›Paper›PMID 37298486›Full record

ArticleInternational journal of molecular sciences2023

Bioenergetic and Cytokine Profiling May Help to Rescue More DCD Livers for Transplantation.

Julia Hofmann, Andras T Meszaros, Madita L Buch, Florian Nardin, Verena Hackl, Carola J Strolz, Bettina Zelger, Margot Fodor, Benno Cardini, Rupert Oberhuber and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Assessment of Mitochondrial Respiration During Hypothermic Storage of Liver Biopsies Following Normothermic Machine Perfusion.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Julia HofmannorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-2791-9215
Andras T MeszarosorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-4732-4374
Madita L BuchorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Florian NardinorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-6486-492X
Verena HacklorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Carola J StrolzorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Bettina ZelgerDepartment of Pathology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Margot FodororganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-3342-2907
Benno CardiniorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Rupert OberhuberorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Thomas ReschorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Annemarie WeissenbacherorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Jakob TroppmairorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-0611-3837
Stefan SchneebergerorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-2619-8639
Theresa HautzorganLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-0388-0202

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The majority of organs used for liver transplantation come from brain-dead donors (DBD). In order to overcome the organ shortage, increasingly donation after circulatory death (DCD) organs are also considered. Since normothermic machine perfusion (NMP) restores metabolic activity and allows for in-depth assessment of organ quality and function prior to transplantation, such organs may benefit from NMP. We herein compare the bioenergetic performance through a comprehensive evaluation of mitochondria by high-resolution respirometry in tissue biopsies and the inflammatory response in DBD and DCD livers during NMP. While livers were indistinguishable by perfusate biomarker assessment and histology, our findings revealed a greater impairment of mitochondrial function in DCD livers after static cold storage compared to DBD livers. During subsequent NMPs, DCD organs recovered and eventually showed a similar performance as DBD livers. Cytokine expression analysis showed no differences in the early phase of NMP, while towards the end of NMP, significantly elevated levels of IL-1β, IL-5 and IL-6 were found in the perfusate of DCD livers. Based on our results, we find it worthwhile to reconsider more DCD organs for transplantation to further extend the donor pool. Therefore, donor organ quality criteria must be developed, which may include an assessment of bioenergetic function and cytokine quantification.

Indexed as

Liver TransplantationTissue and Organ ProcurementEnergy MetabolismHumansLiverOrgan PreservationPerfusionTissue Donorshigh-resolution respirometryliver transplantationmitochondrianormothermic machine perfusion

Identifiers

PMID37298486
PMCPMC10253900

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.