Evidence map›Paper›PMID 37298475›Full record

ArticleInternational journal of molecular sciences2023

Structural and Biological Features of G-Quadruplex Aptamers as Promising Inhibitors of the STAT3 Signaling Pathway.

Veronica Esposito, Daniela Benigno, Ivana Bello, Elisabetta Panza, Mariarosaria Bucci, Antonella Virgilio, Aldo Galeone

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. STAT3 signaling inhibitors for cancer treatment.Trends in pharmacological sciences · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Editorial of Special Issue "Current Trends in Chemistry Towards Biology".International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Veronica EspositoDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, I-80131 Naples, Italy.ORCID 0000-0002-1724-7128
Daniela BenignoDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, I-80131 Naples, Italy.ORCID 0000-0002-5371-1813
Ivana BelloDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, I-80131 Naples, Italy.ORCID 0000-0001-6103-8748
Elisabetta PanzaDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, I-80131 Naples, Italy.ORCID 0000-0003-0274-4671
Mariarosaria BucciDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, I-80131 Naples, Italy.
Antonella VirgilioDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, I-80131 Naples, Italy.ORCID 0000-0002-0873-5250
Aldo GaleoneDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, I-80131 Naples, Italy.ORCID 0000-0001-8805-6348
University of Naples Federico II · IT

Funding

CN00000041 National Center for Gene 'Therapy and Drugs based on RNA Technology', funded by European Union-NextGenerationEU and financed by PNRR MUR-M4C2-Investimento 1.4-CUP UNINA E63C22000940007
6 · The paper itself

Abstract

In this paper, we investigate the structural and biological features of G-quadruplex (G4) aptamers as promising antiproliferative compounds affecting the STAT3 signalling pathway. Targeting the STAT3 protein through high-affinity ligands to reduce its levels or activity in cancer has noteworthy therapeutic potential. T40214 (

Indexed as

Aptamers, NucleotideG-QuadruplexesNeoplasmsCell LineFemaleHumansMaleSignal TransductionSTAT3 Transcription FactorAptamers, NucleotideSTAT3 protein, humanSTAT3 Transcription FactorantiproliferationaptamersG-quadruplexSTAT3

Identifiers

PMID37298475
PMCPMC10253491
OpenAlexW4378904875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.