Evidence map›Paper›PMID 37298469›Full record

ArticleInternational journal of molecular sciences2023

Transcriptome Revealed the Macrophages Inflammatory Response Mechanism and NOD-like Receptor Characterization in Siberian Sturgeon (

Defang Chen, Yinqiu Chen, Lu Lu, Hao Zhu, Xin Zhang, Xiaoli Huang, Zhiqiong Li, Ping Ouyang, Xiaoli Zhang, Liangyu Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Defang ChenAquaculture Department, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Yinqiu ChenAquaculture Department, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Lu LuAquaculture Department, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Hao ZhuAquaculture Department, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Xin ZhangAquaculture Department, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Xiaoli HuangAquaculture Department, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Zhiqiong LiAquaculture Department, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Ping OuyangResearch Center of Aquatic Animal Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Xiaoli ZhangInstitute of Fisheries Research, Chengdu Academy of Agricultural and Forestry Sciences, Chengdu 611130, China.
Liangyu LiInstitute of Fisheries Research, Chengdu Academy of Agricultural and Forestry Sciences, Chengdu 611130, China.
Yi GengResearch Center of Aquatic Animal Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0001-7833-6303
Sichuan Agricultural University · CNChengdu Academy of Agriculture and Forestry Sciences · CN

Funding

Key Research Support Plan NO. 2022-YF09-0040-SNSichuan Natural Science Foundation NO. 2022NSFSC1662
6 · The paper itself

Abstract

Nucleotide-binding and oligomerization domain-like receptors (NOD-like receptors, NLRs) can regulate the inflammatory response to eliminate pathogens and maintain the host's homeostasis. In this study, the head kidney macrophages of Siberian sturgeon were treated with lipopolysaccharide (LPS) to induce inflammation by evaluating the expression of cytokines. The high-throughput sequencing for macrophages after 12 h treatment showed that 1224 differentially expressed genes (DEGs), including 779 upregulated and 445 downregulated, were identified. DEGs mainly focus on pattern recognition receptors (PRRs) and the adaptor proteins, cytokines, and cell adhesion molecules. In the NOD-like receptor signaling pathway, multiple NOD-like receptor family CARD domains containing 3-like (NLRC3-like) were significantly downregulated, and pro-inflammatory cytokines were upregulated. Based on the transcriptome database, 19 NLRs with NACHT structural domains were mined and named in Siberian sturgeon, including 5 NLR-A, 12 NLR-C, and 2 other NLRs. The NLR-C subfamily had the characteristics of expansion of the teleost NLRC3 family and lacked the B30.2 domain compared with other fish. This study revealed the inflammatory response mechanism and NLRs family characterization in Siberian sturgeon by transcriptome and provided basic data for further research on inflammation in teleost.

Indexed as

NLR ProteinsTranscriptomeAnimalsCytokinesFishesFish ProteinsInflammationMacrophagesCytokinesFish ProteinsNLR ProteinsAcipenser baeriicytokinesinflammatory responseLPSNOD-like receptortranscriptome

Identifiers

PMID37298469
PMCPMC10253273
OpenAlexW4378909143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.